Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer
Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer
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DOI：
10.1038/382595a0
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发表时间：
1996-08-15
期刊：
影响因子：
64.8
通讯作者：
DeRobertis, EM
中科院分区：
文献类型：
--
作者：
Bouwmeester, T;Kim, SH;DeRobertis, EM
通过差异筛选，获得了富含Spemann‘s的组织者Cerberus的丰富的c DNA。它编码一种分泌蛋白，在前内胚层表达。将Cerberus mRNA显微注射到非洲爪哇胚胎中，可以诱导异位头部，并复制心脏和肝脏。这些结果表明，在脊椎动物胚胎中，前内胚层中表达的一个分子在诱导头部结构中发挥了作用。
An abundant cDNA enriched in Spemann's organizer, cerberus, was isolated by differential screening. It encodes a secreted protein that is expressed in the anterior endomesoderm. Microinjection of cerberus mRNA into Xenopus embryos induces ectopic heads, and duplicated hearts and livers. The results suggest a role for a molecule expressed in the anterior endoderm in the induction of head structures in the vertebrate embryo.