Microfluidics for synthesis of peptide-based PET tracers.
Microfluidics for synthesis of peptide-based PET tracers.
复制标题
用于合成基于肽的 PET 示踪剂的微流体。
DOI：
10.1155/2013/839683
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发表时间：
2013
影响因子：
--
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Liu Y;Tian M;Zhang H
正电子发射断层扫描（PET）是一种利用PET示踪剂获取人体和动物生理参数的强有力的非侵入性工具。在所有PET示踪剂中，放射性标记的肽由于其对受体的高亲和力和特异性而被广泛探索用于癌症相关受体成像。但是，用于生产基于肽的PET示踪剂的放射化学程序通常很复杂，这使得大规模临床研究相对具有挑战性。新的放射性标记技术，可以简化合成和纯化程序，是非常必要的。在过去的十年中，微流体和芯片实验室（Lab-on-a-chip，简称MEMS）技术作为有机化学领域的强大工具蓬勃发展，这可能为PET化学提供重要帮助。本文综述了微流控放射性标记技术及其在肽类PET示踪剂合成中的应用。
Positron emission tomography (PET) is a powerful noninvasive tool for acquisition of the physiological parameters in human and animals with the help of PET tracers. Among all the PET tracers, radiolabeled peptides have been widely explored for cancer-related receptor imaging due to their high affinity and specificity to receptors. But radiochemistry procedures for production of peptide-based PET tracers are usually complex, which makes large-scale clinical studies relatively challenging. New radiolabeling technologies which could simplify synthesis and purification procedures, are extremely needed. Over the last decade, microfluidics and lab-on-a-chip (LOC) technology have boomed as powerful tools in the field of organic chemistry, which potentially provide significant help to the PET chemistry. In this minireview, microfluidic radiolabeling technology is described and its application for synthesis of peptide-based PET tracers is summarized and discussed.