Validity of Neuropsychological Testing in Young African Children Affected by HIV.
Validity of Neuropsychological Testing in Young African Children Affected by HIV.
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DOI：
10.1055/s-0038-1637020
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发表时间：
2018-09
影响因子：
0.3
通讯作者：
Boivin MJ
中科院分区：
文献类型：
--
作者：
Chernoff MC;Laughton B;Ratswana M;Familiar I;Fairlie L;Vhembo T;Kamthunzi P;Kabugho E;Joyce C;Zimmer B;Ariansen JL;Jean-Philippe P;Boivin MJ
西方设计的神经心理学测试已在低收入和中等收入国家用于评估艾滋病毒/艾滋病和其他慢性疾病的影响。我们探索在撒哈拉以南非洲地区跨文化地使用这些工具。IMPAACT P1104 S是一项为期两年的观察性研究，在6个临床研究中心（南非- 3个研究中心，马拉维，乌干达和津巴布韦）进行，以评估和比较3个队列的5-11岁儿童的神经心理学结果：HIV感染（HIV），HIV暴露但未感染（HEU）和HIV未暴露和未感染（HU）。描述性统计比较了研究中心儿童的社会人口统计学特征。工具包括KABC-II认知能力、TOVA注意力/冲动性、BOT-2运动能力测试和BRIEF执行功能问题。使用组内和斯皮尔曼非参数相关、线性回归和主因子分析评估试验特征。在611名参与者中，50%为男性，平均年龄为6.6至8岁。在马拉维、乌干达和津巴布韦，相当大比例的家庭生活在农村地区，这与南非的情况形成鲜明对比。第0 ~ 48周KABC评分的组内相关系数最高，在0.42 ~ 0.71之间。相似测试领域之间的相关性为低至中度，但显著，KABC序贯与TOVA评分呈正相关，BRIEF与KABC评分呈负相关。TOVA反应时间评分与BOT-2总分评分呈负相关。观察到生长、残疾和发育的个人测量与所有测试分数之间存在强有力的显著关联。即使在控制了年龄、性别和地点之后，基于绩效的措施对艾滋病毒的影响也明显低于高浓缩铀和高浓缩铀参与者。因子分析证实了KABC量表项目得分的基本理论结构。KABC、TOVA、BRIEF和BOT-2是评估四个撒哈拉以南非洲国家艾滋病毒的神经心理影响的有效和可靠工具。
Western-constructed neuropsychological tests have been used in low and middle income countries to assess the impact of HIV/AIDS and other chronic illnesses. We explore using such instruments cross-culturally in a sub-Saharan Africa setting. IMPAACT P1104S was a two-year observational study carried out at six clinical sites (South Africa- 3 sites, Malawi, Uganda and Zimbabwe) to assess and compare neuropsychological outcomes in three cohorts of children 5–11 years of age: HIV-infected (HIV), HIV-exposed but uninfected (HEU) and HIV unexposed and uninfected (HU). Descriptive statistics compared socio-demographic characteristics among children at sites. Instruments included the KABC-II cognitive ability, TOVA attention/impulsivity, BOT-2 motor proficiency tests, and BRIEF executive function problems. Test characteristics were assessed using intraclass and Spearman non-parametric correlations, linear regression and principal factor analyses. Of the 611 participants, 50% were male and mean age ranged from 6.6 to 8 years. In Malawi, Uganda and Zimbabwe, substantial proportions of families lived in rural settings in contrast to the South African sites. Intraclass correlation coefficients between weeks 0 and 48 were highest for the KABC scores, ranging between 0.42 to 0.71.Correlations among similar test domains were low to moderate but significant, with positive correlation between KABC Sequential and TOVA scores and negative correlation between BRIEF and KABC scores. TOVA response time scores correlated negatively with the BOT-2 Total points score. Strong and significant associations between individual measures of growth, disability and development with all test scores were observed. Performance-based measures were markedly lower for HIV compared to HEU and HU participants, even after controlling for age, sex and site. Factor analyses confirmed the underlying theoretical structure of the KABC scaled item scores. The KABC, TOVA, BRIEF and BOT-2 were valid and reliable tools for assessing the neuropsychological impact of HIV in four sub-Saharan African countries.
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DOI：
10.1097/dbp.0000000000000149
发表时间：
2015-05
期刊：
Journal of developmental and behavioral pediatrics : JDBP
影响因子：
--
作者：
Familiar I;Ruisenor-Escudero H;Giordani B;Bangirana P;Nakasujja N;Opoka R;Boivin M
通讯作者：
Boivin M
影响因子：
2.6
作者：
Bangirana P;Allebeck P;Boivin MJ;John CC;Page C;Ehnvall A;Musisi S
通讯作者：
Musisi S
在乌干达学龄儿童中对Cogstate电池进行快速神经认知评估的验证。
影响因子：
5.6
作者：
Bangirana P;Sikorskii A;Giordani B;Nakasujja N;Boivin MJ
通讯作者：
Boivin MJ
DOI：
10.1097/qad.0000000000001683
发表时间：
2018-01-14
期刊：
AIDS (London, England)
影响因子：
--
作者：
Boivin MJ;Barlow-Mosha L;Chernoff MC;Laughton B;Zimmer B;Joyce C;Bwakura-Dangarembizi M;Ratswana M;Abrahams N;Fairlie L;Gous H;Kamthunzi P;McCarthy K;Familiar-Lopez I;Jean-Phillippe P;Coetzee J;Violari A;Cotton MF;Palumbo PE;IMPAACT P1104s Study Team
通讯作者：
IMPAACT P1104s Study Team
影响因子：
3.7
作者：
Bangirana, Paul;John, Chandy C.;Boivin, Michael J.
通讯作者：
Boivin, Michael J.