Prevention of preeclampsia by linoleic acid and calcium supplementation: A randomized controlled trial
Prevention of preeclampsia by linoleic acid and calcium supplementation: A randomized controlled trial
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DOI：
10.1016/s0029-7844(97)00711-4
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发表时间：
1998-04-01
影响因子：
7.2
通讯作者：
Herrera, S
中科院分区：
文献类型：
--
作者：
Herrera, JA;Arevalo-Herrera, M;Herrera, S
目的：确定低剂量亚油酸和钙对前列腺素（PG）水平的影响以及这种治疗在预防先兆子痫中的功效。方法：在一项随机、双盲、安慰剂对照研究中，我们治疗了86名有先兆子痫危险因素的孕妇（高生物心理社会风险[3分以上]，滚转试验阳性，和高平均血压[高于85 mmHg）]，每日剂量为450 mg亚油酸和600 mg钙（n = 43）或450 mg淀粉和600 mg乳糖安慰剂（n = 43）结果：实验组有4例（9.3%）发生先兆子痫，对照组有16例（37.2%）发生先兆子痫（相对危险度0.25，95%可信区间0.09，0.69，P <0.001）。治疗4周后，实验组中PGE（2）的中位血清水平增加了106%（P = 0.03），对照组下降了33%（P = 0.02）。血栓素B-2和PGE（2）的中位比值在实验组中下降了40%（P = 0.02），在对照组中上升了18%（P = 0.14）。两组中血栓素B-2和6-酮FGF（1 α）的中位比值均无显著差异。没有严重的母亲或新生儿的治疗副作用发生在任一group.Conclusion：低剂量的亚油酸和钙在妊娠晚期的管理，降低先兆子痫的发病率显着的妇女在高危，可能通过纠正PGE（2）水平。(C)1998年由美国妇产科医师学会。
Objective: To determine the effect of low doses of linoleic acid and calcium on prostaglandin (PG) levels and the efficacy of this treatment in the prevention of preeclampsia.Methods: In a randomized, double-blind, placebo-controlled study we treated 86 primigravidas with risk factors for preeclampsia (high biopsychosocial risk [above 3 points], positive roll-over test, and high mean blood pressure [above 85 mmHg)] with daily doses of either 450 mg linoleic acid and 600 mg calcium (n = 43) or 450 mg starch and 600 mg lactose placebo (n = 43) during the third trimester of pregnancy.Results: Four women in the experimental group (9.3%) developed preeclampsia compared with 16 (37.2%) controls (relative risk 0.25, 95% confidence interval 0.09, 0.69, P < .001). The median serum levels of PGE(2) after 4 weeks of treatment increased by 106% in the experimental group (P = .03) and decreased by 33% in the control group (P = .02). The median ratio between thromboxane B-2 and PGE(2) decreased by 40% in the experimental group (P = .02) and increased by 18% in the control group (P = .14). No significant differences were observed in the median ratio between thromboxane B-2 and 6-keto FGF(1 alpha) in either group. No serious maternal or neonatal side effects of treatment occurred in either group.Conclusion: The administration of low daily doses of linoleic acid and calcium during the third trimester of pregnancy reduced the incidence of preeclampsia significantly in women at high risk, possibly by correcting the PGE(2) levels. (C) 1998 by The American College of Obstetricians and Gynecologists.