Clinical manifestations associated with HTLV type I infection:: A cross-sectional study
Clinical manifestations associated with HTLV type I infection:: A cross-sectional study
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DOI：
10.1089/aid.2006.0140
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发表时间：
2007-03-01
影响因子：
1.5
通讯作者：
Glesby, Marshall J.
中科院分区：
文献类型：
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作者：
Caskey, Marina F.;Morgan, Daniel J.;Glesby, Marshall J.
人类嗜T淋巴细胞病毒I型（HTLV-I）在一小部分感染个体中引起HTLV-I相关的脊髓病/热带痉挛性下肢轻瘫和成人T细胞白血病。HTLV-I感染越来越多地与临床表现相关。为了确定HTLVI感染者临床表现的患病率，我们对115名无脊髓病的HTLV-I感染献血者和115名年龄和性别匹配的血清阴性对照进行了横断面研究。受试者回答标准化问卷并进行体格检查。与对照组相比，HTLV-I感染的受试者更容易报告手臂或腿部无力（OR = 3.8，95%CI：1.4-10.2; OR = 4.0，95%CI：1.6-9.8），手足麻木（OR = 2.1，95% CI：1.1-3.9; OR = 4.8，95% CI：2.0-11.7），关节痛（OR = 3.3，95% CI：1.7-6.4），（OR = 2.7，95%CI：1.04-6.8），勃起功能障碍（OR = 4.0，95%CI：1.6 = 9.8），并有牙龈炎牙周炎（OR = 10.0，95%CI：2.3 - 42.8）和口腔粘膜干燥（OR = 7.5，95%CI：1.7 - 32.8）。HTLV-I感染与多种临床表现相关，可能发生在未发生脊髓病的患者中。
Human T-lymphotropic virus type I (HTLV-I) causes HTLV-I-associated myelopathy/tropical spastic paraparesis and adult T cell leukemia in a small percentage of infected individuals. HTLV-I infection is increasingly associated with clinical manifestations. To determine the prevalence of clinical manifestations in HTLVI infected individuals, we conducted a cross-sectional study of 115 HTLV-I-infected blood donors without myelopathy and 115 age- and sex-matched seronegative controls. Subjects answered a standardized questionnaire and underwent physical examination. Compared with controls, HTLV-I-infected subjects were more likely to report arm or leg weakness (OR = 3.8, 95% CI: 1.4-10.2; OR = 4.0, 95% CI: 1.6-9.8, respectively), hand or foot numbness (OR = 2.1, 95% CI: 1.1-3.9; OR = 4.8, 95% CI: 2.0-11.7, respectively), arthralgia (OR = 3.3, 95% CI: 1.7-6.4), nocturia (OR = 2.7, 95% CI: 1.04-6.8), erectile dysfunction ( OR = 4.0, 95% CI: 1.6 = 9.8), and to have gingivitis (OR = 3.8, 95% CI: 1.8 - 7.9), periodontitis (OR = 10.0, 95% CI: 2.3 - 42.8), and dry oral mucosa (OR = 7.5, 95% CI: 1.7 - 32.8). HTLV-I infection is associated with a variety of clinical manifestations, which may occur in patients who have not developed myelopathy.