Tumor-infiltrating CD8+T cells combined with tumor-associated CD68+macrophages predict postoperative prognosis and adjuvant chemotherapy benefit in resected gastric cancer
Tumor-infiltrating CD8+T cells combined with tumor-associated CD68+macrophages predict postoperative prognosis and adjuvant chemotherapy benefit in resected gastric cancer
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DOI：
10.1186/s12885-019-6089-z
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发表时间：
2019-09-14
期刊：
影响因子：
3.8
通讯作者：
Huang, Chang-ming
中科院分区：
文献类型：
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作者：
Lu, Jun;Xu, Yu;Huang, Chang-ming
背景：肿瘤浸润免疫细胞存在于各种恶性肿瘤中，但其在胃癌（GC）中的临床意义仍不明确。本研究旨在探讨肿瘤浸润淋巴细胞（TILs）和肿瘤相关巨噬细胞（TAMs）的预后意义。
方法：利用一个包含401例胃癌病例的前瞻性数据库，我们通过免疫组化染色评估TIL（分化群8（CD8）表达）和TAM（分化群68（CD68）表达）的状态。
结果：与CD8 + TIL阴性病例（n = 196，48.6%）相比，CD8 + TIL阳性病例（n = 205，51.1%）显示出显著更好的无复发生存期（RFS）[对数秩检验p
Background Tumor-infiltrating immune cells are present in various malignant tumors, but their clinical significance in gastric cancer (GC) remains unclear. This study aimed to investigate the prognostic significance of tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs). Methods Using a prospective database containing 401 cases of GC, we evaluated TIL (cluster of differentiation 8 (CD8) expression) and TAM (cluster of differentiation 68 (CD68) expression) statuses via immunohistochemical staining. Results Compared with CD8+ TIL-negative cases (n = 196, 48.6%), CD8+ TIL-positive cases (n = 205, 51.1%) showed significantly better recurrence-free survival (RFS) [log-rank p