Oocyte maturation inhibitor.
Oocyte maturation inhibitor.
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卵母细胞成熟抑制剂。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
S. Pomerantz
中科院分区：
文献类型：
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作者：
A. Tsafriri;S. Pomerantz
排卵前促性腺激素的激增在成熟的Graafian卵泡内引起一系列变化，最终释放可受精的卵子。这些包括减数分裂的恢复，出生后很短时间内暂停的过程，以及卵母细胞从网状细胞阶段到第二次减数分裂中期的进展。在这里，卵泡因子，卵母细胞成熟抑制剂（OMI），在阻止恢复减数分裂的卵子窦卵泡前促性腺激素激增的作用进行了审查。OMI参与减数分裂的调节是基于以下观察结果：（1）从卵泡中分离出来的成熟卵母细胞自发地进行减数分裂成熟，而卵泡封闭的卵子在受到刺激之前仍然是未成熟的：（2）从卵泡中分离出来的卵母细胞与卵泡颗粒细胞、颗粒细胞提取物和卵泡液共培养抑制自发成熟;（3）OMI对卵母细胞成熟的抑制作用是可逆的，并且在所采用的几种模型中，可以通过加入减数分裂的生理触发物促黄体生成素（LH）来消除。OMI的表征和纯化的当前状态已被描述和参与额外的因素，如环AMP，在减数分裂的调节进行了讨论。
The preovulatory surge of gonadotropins induces within the mature Graafian follicle a series of changes culminating in the release of a fertilizable ovum. These include resumption of the meiotic division, a process held in abeyance from a short time after birth, and the progression of the oocyte from the dictyate stage to the metaphase of the second meiotic division. Here the role of a follicular factor, oocyte maturation inhibitor (OMI), in preventing resumption of meiosis by ova of antral follicles prior to the surge of gonadotropins has been reviewed. The suggested involvement of OMI in regulation of meiosis is based on the following observations: (1) fully grown mammalian oocytes explanted from their follicles undergo meiotic maturation spontaneously, whereas follicle-enclosed ova remain immature until stimulated; (2) co-culture of oocytes isolated from their follicles with follicular granulosa cells, granulosa cell extract and follicular fluid inhibits the spontaneous maturation; (3) the inhibition of oocyte maturation by OMI is reversible and in several of the models employed can be removed by the addition of the physiological trigger of meiosis, luteinizing hormone (LH). The current state of OMI characterization and purification has been described and the involvement of additional factors, such as cyclic AMP, in the regulation of meiosis discussed.