Prenatal Tobacco Exposure Shortens Telomere Length in Children
Prenatal Tobacco Exposure Shortens Telomere Length in Children
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DOI：
10.1093/ntr/ntw139
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发表时间：
2017-01-01
影响因子：
4.7
通讯作者：
Lau, Yu Lung
中科院分区：
文献类型：
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作者：
Ip, Patrick;Chung, Brian Hon Yin;Lau, Yu Lung
初步证据表明，产前烟草暴露与儿童端粒长度之间可能存在关联。本研究进行调查是否母亲在怀孕期间吸烟与端粒缩短在他们的孩子，是否产前和儿童期暴露于环境烟草有任何影响这个association.Methods：这是一个人口代表性的研究产前烟草暴露和端粒长度之间的关联儿童。采用分层随机抽样的方法，从人群健康研究中招募了98名15岁以下的香港中国儿童，他们在产前有烟草暴露，并与98名年龄和性别相匹配的对照组进行了比较。产前烟草暴露儿童的端粒长度明显短于未暴露儿童（暴露组的平均T/S比= 24.9 [SD = 8.58]，对照组为28.97 [14.15]; P = 0.02）。在T/S比值和烟草暴露时间之间观察到负剂量反应关系：母亲在怀孕期间吸烟的时间越长，孩子的端粒长度越短。儿童的端粒长度和产前烟草暴露之间的关联仍然显着的家庭社会经济地位和暴露于环境烟草烟雾在怀孕和childhood.Conclusions的影响后，产前烟草暴露与端粒缩短儿童。由于这可能会通过胎儿的遗传编程施加显着的健康影响，应作出更多的努力，以减少胎儿烟草暴露，教育孕妇不吸烟，激励吸烟者戒烟，在早期pregnancy.Implications：反映端粒缩短，产前烟草暴露在儿童可能会导致过早衰老和健康风险增加，我们建议是完全可以预防的。怀孕期间不吸烟或戒烟对于改善我们后代的健康状况至关重要，因为产前烟草暴露可能会影响儿童的生物编程。
Introduction: Preliminary evidence suggests a possible association between prenatal tobacco exposure and telomere length in children. This study was conducted to investigate whether maternal smoking during pregnancy was associated with telomere shortening in their children and whether prenatal and childhood exposure to environmental tobacco had any impact on this association.Methods: This is a population-representative study on the association between prenatal tobacco exposure and telomere length in children. Ninety-eight Hong Kong Chinese children aged under 15 years with prenatal tobacco exposure and 98 age-and gender-matched controls were recruited from a population health study with stratified random sampling.Results: Telomere length in children with prenatal tobacco exposure was significantly shorter than in those with no exposure (mean T/S ratio = 24.9 [SD = 8.58] in exposed vs. 28.97 [14.15] in control groups; P = 0.02). A negative dose-response relationship was observed between the T/S ratio and tobacco exposure duration: the longer the duration of maternal smoking in pregnancy, the shorter the child's telomere length. The association between the child's telomere length and prenatal tobacco exposure remained significant after considering the influence of family socioeconomic status and exposure to environmental tobacco smoke during pregnancy and childhood.Conclusions: Prenatal tobacco exposure was associated with telomere shortening in children. As this may impose significant health impacts through fetal genetic programming, more efforts should be made to reduce fetal tobacco exposure by educating pregnant women to not smoke and motivating smokers to quit in early pregnancy.Implications: As reflected by telomere shortening, prenatal tobacco exposure in children can cause premature aging and increased health risks, which we suggest is entirely preventable. Not smoking during pregnancy or quitting smoking is critical to improving the health outcome of our future generations as prenatal tobacco exposure may affect children's biological programming.