Circulating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity
Circulating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity
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DOI：
10.1016/j.numecd.2016.06.001
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发表时间：
2016-11-01
影响因子：
3.9
通讯作者：
Gnessi, L.
中科院分区：
文献类型：
--
作者：
Mariani, S.;Costantini, D.;Gnessi, L.
背景和目的：肥胖在全球范围内日益增加，并与不良心血管结局相关。心外膜脂肪（EF），心脏内脏脂肪库，随着肥胖而增加，并与心血管风险相关。SIRT 1是一种调节与肥胖相关的代谢回路的酶，具有心脏保护作用，是心血管事件的预测因子。我们的目的是评估EF厚度（EFT）与循环SIRT 1在patients with obesity.Methods and results：62例肥胖患者和23瘦对照进行了研究。采用酶联免疫吸附试验（ELISA）测定血浆SIRT 1浓度。超声心动图测量EFT。评估体重指数（BMI）、腰围、心率（HR）、血压和实验室检查结果（空腹血糖、胰岛素、HbA 1c、胆固醇和甘油三酯）。与瘦对照组相比，肥胖患者的SIRT 1显著降低（P = 0.002），EFT显著升高（P < 0.0001）。肥胖组SIRT 1与EFT、HR呈负相关（rho =-0.350，P = 0.005; rho =-0.303，P = 0.008）。校正肥胖相关变量后，多元线性回归分析显示，EFT与SIRT 1的相关性最好（β =-0.352，P = 0.016）。血清SIRT 1水平可能为肥胖患者冠状动脉疾病风险评估提供额外信息。(C)2016年意大利糖尿病学会、意大利动脉粥样硬化研究学会、意大利人类营养学会和费德里科二世大学临床医学和外科系。Elsevier B. V.出版，保留所有权利。
Background and aim: Obesity is increasing worldwide and is related to undesirable cardiovascular outcomes. Epicardial fat (EF), the heart visceral fat depot, increases with obesity and correlates with cardiovascular risk. SIRT1, an enzyme regulating metabolic circuits linked with obesity, has a cardioprotective effect and is a predictor of cardiovascular events. We aimed to assess the relationship of EF thickness (EFT) with circulating SIRT1 in patients with obesity.Methods and results: Sixty-two patients affected by obesity and 23 lean controls were studied. Plasma SIRT1 concentration was determined by enzyme-linked immunosorbent assay (ELISA). EFT was measured by echocardiography. Body mass index (BMI), waist circumference, heart rate (HR), blood pressure, and laboratory findings (fasting glucose, insulin, HbA1c, cholesterol, and triglycerides) were assessed. SIRT1 was significantly lower (P = 0.002) and EFT was higher (P < 0.0001) in patients with obesity compared with lean controls. SIRT1 showed a negative correlation with EFT and HR in the obesity group (rho = -0.350, P = 0.005; rho = -0.303, P = 0.008, respectively). After adjustment for obesity-correlated variables, multiple linear regression analysis showed that EFT remained the best correlate of SIRT1 (beta = -0.352, P = 0.016).Conclusions: Circulating SIRT1 correlates with the visceral fat content of the heart. Serum SIRT1 levels might provide additional information for risk assessment of coronary artery disease in patients with obesity. (C) 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.