Calcium antagonists and atherosclerosis.
Calcium antagonists and atherosclerosis.
复制标题
钙拮抗剂和动脉粥样硬化。
DOI：
10.1007/978-1-4613-2459-1_25
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发表时间：
1985
影响因子：
--
通讯作者：
Kramsch,DM
中科院分区：
文献类型：
--
作者：
Kramsch,DM
人类动脉粥样硬化的临床重要病变是经常钙化的纤维粥样斑块。1纤维病变的结缔组织变化开始在生命的第二个十年发展，但通常需要几十年的缓慢生长才能产生临床症状。然而，正是这些结缔组织变化通过以下方式严重损害动脉功能而威胁健康和生命：纤维内膜升高导致管腔狭窄，弹性膜破坏和胶原蛋白积聚导致弹性丧失，以及钙矿化导致刚性和脆性增加。这些动脉功能的损害反过来导致血流不足、血栓形成、高血压、动脉瘤和血管破裂。
The clinically important lesion of human atherosclerosis is the fibrous atheromatous plaque which often is calcified.1The connective tissue changes of fibrous lesions begin to develop in the second decade of life but it usually takes decades of slow growth before they produce clinical symptoms. However, it is these connective tissue changes which threaten health and life by seriously impairing arterial function through: luminal stenoses by the raised fibrous intima, through loss of elasticity by elastica destruction and collagen accumulation, as well as through increased rigidity and brittleness by calcium mineralization. These impairments of arterial function in turn lead to insufficiency of blood flow, thrombosis, hypertension, aneurysms and vessel rupture.