THE EFFECT OF INTRAUTERINE PCB EXPOSURE ON VISUAL RECOGNITION MEMORY
THE EFFECT OF INTRAUTERINE PCB EXPOSURE ON VISUAL RECOGNITION MEMORY
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DOI：
10.2307/1130097
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发表时间：
1985-01-01
影响因子：
4.6
通讯作者：
DOWLER, JK
中科院分区：
文献类型：
--
作者：
JACOBSON, SW;FEIN, GG;DOWLER, JK
不良新生儿结局与宫内暴露于多氯联苯（PCB）有关。在一项对暴露和未暴露婴儿的随访研究中，123名出生时接受测试的婴儿在7个月时接受了Fagan视觉识别记忆测试。产前PCB暴露，脐带血清PCB水平和母亲报告的污染鱼类消费的两项措施，都预测不喜欢一种新的刺激。随着产前多氯联苯暴露水平的增加，对新奇事物的偏好以剂量依赖的方式下降。产后护理暴露与视觉识别记忆无关。产前暴露和视觉识别之间的关系是不介导的新生儿赤字，表明宫内PCB暴露可能有一个延迟的影响中枢神经系统功能。
Adverse neonatal outcomes have been associated with intrauterine exposure to polychlorinated biphenyls (PCB). In a follow-up study of exposed and nonexposed infants, 123 infants tested at birth were administered Fagan''s test of visual recognition memory at 7 mo. Two measures of prenatal PCB exposure, cord serum PCB level and maternal report of contaminated fish consumption, both predicted less preference for a novel stimulus. Preference for novelty decreased in a dose-dependent fashion with increasing levels of prenatal PCB exposure. Postnatal exposure from nursing was not related to visual recognition memory. The relation between prenatal exposure and visual recognition was not mediated by the neonatal deficits, suggesting that intrauterine PCB exposure may have a delayed effect on CNS functioning.