ENHANCED SPATIAL DISCRIMINATION-LEARNING IN RATS FOLLOWING 5,7-DHT-INDUCED SEROTONERGIC DEAFFERENTATION OF THE HIPPOCAMPUS
ENHANCED SPATIAL DISCRIMINATION-LEARNING IN RATS FOLLOWING 5,7-DHT-INDUCED SEROTONERGIC DEAFFERENTATION OF THE HIPPOCAMPUS
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DOI：
10.1016/0006-8993(90)90954-a
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发表时间：
1990-06-04
期刊：
影响因子：
2.9
通讯作者：
AZMITIA, EC
中科院分区：
文献类型：
--
作者：
ALTMAN, HJ;NORMILE, HJ;AZMITIA, EC
在 Stone 14 单元 T 型迷宫中训练的大鼠的学习能力，是在对海马体的血清素输入进行细胞毒性（5,7-二羟色胺；5,7-DHT）传入阻滞后评估的一项复杂的、正强化的空间辨别任务。通过将细胞毒素注入穹窿伞/扣带束来实现血清素能传入神经阻滞。与注射载体或假操作的对照组相比，受损大鼠在显着更少的试验中达到标准（即学习），并且在整个训练过程中犯的错误显着更少。这是首次研究选择性慢性破坏海马体血清素输入的影响。因此，目前的结果提供了支持大鼠海马内血清素（5-HT）在调节该任务的学习和记忆过程中的神经调节作用的证据。因此，有必要进行其他研究，以确定海马 5-HT 是否也在其他类型任务中的学习和记忆过程的调节中发挥作用。
Learning in rats trained in the Stone 14-unit T-maze, a complex, positively reinforced spatial discrimination task was assessed following cytotoxic (5,7-dihydroxytryptamine; 5,7-DHT) deafferentation of the serotonergic inputs to the hippocampus. Serotonergic deafferentation was accomplished by infusing the cytotoxin in to the fornix-fimbria/cingulum bundle. Lesioned rats reached criterion (i.e. learned) in significantly fewer trials and made significantly fewer errors throughout training than either vehicle-injected or sham-operated controls. This represents the first time that the effects of selective chronic destruction of serotonergic inputs to the hippocampus have been investigated. The present results provide, therefore, evidence in support of a neuromodulatory role for serotonin (5-HT) within the rat hippocampus in the mediation of the processes underlying learning and memory for this task. Other studies are, therefore, warranted in order to determine whether hippocampal 5-HT also plays a role in the mediation of the processes underlying learning and memory in other types of tasks.