Structure of the armadillo repeat domain of plakophilin 1
Structure of the armadillo repeat domain of plakophilin 1
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DOI：
10.1016/j.jmb.2004.11.048
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发表时间：
2005-02-11
影响因子：
5.6
通讯作者：
Weis, WI
中科院分区：
文献类型：
--
作者：
Choi, HJ;Weis, WI
p120（ctn）亚家族的犰狳结构域蛋白在调节细胞间粘附的钙粘蛋白连接的作用。我们已经确定了从plakophilin-1（PKP 1），一个成员的p120（ctn）亚家族的臂重复结构域的晶体结构中发现桥粒。结构揭示了该结构域具有9个而不是预期的10个臂重复。预测为臂重复的序列反而是大插入物，其充当在整个结构域结构中产生显著弯曲的楔形物。基于结构的序列比对表明，九个重复和大插入是常见的这个亚家族的犰狳蛋白。蛋白质表面上的一个突出的碱性补丁可以作为这些蛋白质的伴侣的结合位点。(C)2004爱思唯尔有限公司保留所有权利。
The p120(ctn) subfamily of armadillo domain proteins has roles in modulating intercellular adhesion by cadherin-containing junctions. We have determined the crystal structure of the arm repeat domain from plakophilin-1 (PKP1), a member of the p120(ctn) subfamily that is found in desmosomes. The structure reveals that the domain has nine instead of the expected ten arm repeats. A sequence predicted to be an arm repeat is instead a large insert which serves as a wedge that produces a significant bend in the overall domain structure. Structure-based sequence alignments indicate that the nine repeats and large insert are common to this subfamily of armadillo proteins. A prominent basic patch on the surface of the protein may serve as a binding site for partners of these proteins. (C) 2004 Elsevier Ltd. All rights reserved.