Rho GTPases and the actin cytoskeleton
Rho GTPases and the actin cytoskeleton
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DOI：
10.1126/science.279.5350.509
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发表时间：
1998-01-23
期刊：
影响因子：
56.9
通讯作者：
Hall, A
中科院分区：
文献类型：
--
作者：
Hall, A
肌动蛋白细胞骨架在所有真核细胞中介导各种基本的生物学功能。除了提供一个结构框架，围绕该框架确定细胞形状和极性之外，其动力学特性还为细胞移动和分裂提供驱动力。因此，了解控制肌动蛋白组织的生化机制是当代细胞生物学的一个主要目标，对健康和疾病有影响。小鸟苷三磷酸酶Rho家族的成员已经成为肌动蛋白细胞骨架的关键调节剂，此外，通过与多种靶蛋白的相互作用，它们确保协调控制其他细胞活动，如基因转录和粘附。
The actin cytoskeleton mediates a variety of essential biological functions in all eukaryotic cells. in addition to providing a structural framework around which cell shape and polarity are defined, its dynamic properties provide the driving force for cells to move and to divide. Understanding the biochemical mechanisms that control the organization of actin is thus a major goal of contemporary cell biology, with implications for health and disease. Members of the Rho family of small guanosine triphosphatases have emerged as key regulators of the actin cytoskeleton, and furthermore, through their interaction with multiple target proteins, they ensure coordinated control of other cellular activities such as gene transcription and adhesion.