INFLUENCE OF THE DEVELOPMENT OF DIABETES-MELLITUS ON CLINICAL STATUS IN PATIENTS WITH CYSTIC-FIBROSIS
INFLUENCE OF THE DEVELOPMENT OF DIABETES-MELLITUS ON CLINICAL STATUS IN PATIENTS WITH CYSTIC-FIBROSIS
复制标题
DOI：
10.1007/bf01957574
复制
发表时间：
1992-09-01
影响因子：
3.6
通讯作者：
KOCH, C
中科院分区：
文献类型：
--
作者：
LANNG, S;THORSTEINSSON, B;KOCH, C
回顾性研究了38例囊性纤维化（CF）合并糖尿病（DM）患者和38例非糖尿病CF患者（对照组）中糖尿病前期对临床状态的影响，这些患者在年龄、性别和慢性铜绿假单胞菌肺部感染方面配对。在索引病例中，在诊断为DM之前6年收集CF临床状态的季度参数。与对照组相比，糖尿病前期患者体重、体重指数（BMI）、第一秒用力呼气容积（FEV1）和用力肺活量（FVC）降低，每日胰酶胶囊摄入量增加。糖尿病前期患者和对照组患者的体重、BMI、FEV1、FVC和胰酶胶囊摄入量分别在糖尿病诊断前4年、4年、1.25年、3年和4.5年出现统计学显著差异。两组患者的肺部感染数量没有差异。因此，当CF患者发生DM时，在其诊断前数年内观察到总体临床状态的隐性下降。目前尚不清楚CF的临床恶化是否导致DM，或糖尿病前期是否导致CF临床状态下降。越来越多的证据表明，后者可能是这种情况，因为胰岛素治疗似乎可以改善CF的肺功能。
The impact of pre-diabetes on clinical status was retrospectively studied in 38 cystic fibrosis (CF) patients with diabetes mellitus (DM) and 38 non-diabetic CF patients (control patients), matched in pairs for age, sex, and chronic Pseudomonas aeruginosa lung infection. Quarterly parameters of CF clinical status were collected for 6 years prior to the diagnosis of DM in the index case. Compared to the control patients, decreases in body weight, body mass index (BMI), forced expiratory volume in 1s (FEV1), and forced vital capacity (FVC) and an increase in the daily intake of pancreatic enzyme capsules were found in the pre-diabetic patients. Statistically significant differences in body weight, BMI, FEV1, FVC, and intake of pancreatic enzyme capsules between pre-diabetic and control patients emerged 4, 4, 1.25, 3 and 4.5 years prior to the diagnosis of DM, respectively. The number of lung infections did not differ between the two groups of patients. Thus, when DM develops in CF patients, an insidious decline in overall clinical status is observed for years prior to its diagnosis. Whether clinical deterioration in CF leads to DM, or pre-diabetes results in declining CF clinical status is presently unknown. Accumulating evidence suggests that the latter may be the case since insulin therapy seems to improve lung function in CF.