ACELLULAR PERTUSSIS-VACCINE IN ADULTS - ADVERSE REACTIONS AND IMMUNE-RESPONSE
ACELLULAR PERTUSSIS-VACCINE IN ADULTS - ADVERSE REACTIONS AND IMMUNE-RESPONSE
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DOI：
10.1007/bf02097184
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发表时间：
1987-02-01
影响因子：
4.5
通讯作者：
SATO, Y
中科院分区：
文献类型：
--
作者：
GRANSTROM, M;THOREN, M;SATO, Y
在成人志愿者中评价了含有百日咳毒素和丝状血凝素的无细胞百日咳疫苗JNIH-6的不良反应和抗体应答。不良反应少且轻微。在47名接种者中的22名（47%）中观察到迟发性局部反应，而接受安慰剂（疫苗的磷酸铝载体溶液）的20名受试者中无一人出现迟发性局部反应。接种后第6 - 8天出现的反应包括大多数受试者认为不显著的硬结和/或肿胀。该反应仅见于接种第一剂疫苗的接种者，与接种前抗毒素水平无关。该疫苗诱导了对丝状血凝素和百日咳毒素的高度满意的抗体应答。
An acellular pertussis vaccine JNIH-6 containing pertussis toxin and filamentous hemagglutinin was evaluated in adult volunteers with regard to adverse reactions and antibody response. Adverse reactions were few and mild. A late onset local reaction was seen in 22 of the 47 vaccinees (47%) as compared to none of the 20 subjects receiving a placebo, the carrier solution of aluminium phosphate of the vaccine. The reaction, which manifested itself on the 6th to 8th day after vaccination, consisted in all cases of an induration and/or swelling considered insignificant by the majority of the subjects. The reaction was only found in vaccinees receiving a first dose of vaccine and was independent of the prevaccination antitoxin level. The vaccine induced a highly satisfactory antibody response to both filamentous hemagglutinin and pertussis toxin.