Lung cancer risk and pollution in an industrial region of Northern Spain: a hospital-based case-control study.
Lung cancer risk and pollution in an industrial region of Northern Spain: a hospital-based case-control study.
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DOI：
10.1186/1476-072x-10-10
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发表时间：
2011-01-25
影响因子：
4.9
通讯作者：
Pollán M
中科院分区：
文献类型：
--
作者：
López-Cima MF;García-Pérez J;Pérez-Gómez B;Aragonés N;López-Abente G;Tardón A;Pollán M
阿斯图里亚斯是西班牙北方的一个自治区，拥有一个大工业区，肺癌发病率和死亡率都很高。虽然这种肺癌的过度风险可能部分归因于吸烟习惯和职业暴露，但也需要评估工业和城市污染的作用。目的是确定阿斯图里亚斯城市和工业空气污染对肺癌风险的可能影响。这是一项以医院为基础的病例对照研究，包括在阿斯图里亚斯招募的626名肺癌患者和626名对照，并按种族、医院、年龄和性别进行匹配。计算了从各个参与者的住宅位置到工业设施和市中心的距离。使用逻辑回归，计算了与城市和工业污染源距离的优势比（OR）和95%置信区间（95%CI），并对性别、年龄、医院面积、烟草消费、癌症家族史和职业进行了调整。然而，居住在工业区附近的人患肺癌的风险过高，（OR = 1.49，95%CI = 0.93-2.39），在小细胞癌中具有统计学意义（OR = 2.23，95%CI = 1.01-4.92），城市居民腺癌的危险性显著增加（OR = 1.92; 95%CI = 1.09-3.38）。在希洪健康区，市区居民登记的肺癌风险在统计学上显著增加（OR = 2.17; 95%CI = 1.25-3.76），而在阿维莱斯健康区，未发现暴露区域的风险差异。这项研究提供了进一步的证据，证明空气污染是肺癌的中度危险因素。
Asturias, an Autonomous Region in Northern Spain with a large industrial area, registers high lung cancer incidence and mortality. While this excess risk of lung cancer might be partially attributable to smoking habit and occupational exposure, the role of industrial and urban pollution also needs to be assessed. The objective was to ascertain the possible effect of air pollution, both urban and industrial, on lung cancer risk in Asturias. This was a hospital-based case-control study covering 626 lung cancer patients and 626 controls recruited in Asturias and matched by ethnicity, hospital, age, and sex. Distances from the respective participants' residential locations to industrial facilities and city centers were computed. Using logistic regression, odds ratios (ORs) and 95% confidence intervals (95%CIs) for categories of distance to urban and industrial pollution sources were calculated, with adjustment for sex, age, hospital area, tobacco consumption, family history of cancer, and occupation. Whereas individuals living near industries displayed an excess risk of lung cancer (OR = 1.49; 95%CI = 0.93-2.39), which attained statistical significance for small cell carcinomas (OR = 2.23; 95%CI = 1.01-4.92), residents in urban areas showed a statistically significant increased risk for adenocarcinoma (OR = 1.92; 95%CI = 1.09-3.38). In the Gijon health area, residents in the urban area registered a statistically significant increased risk of lung cancer (OR = 2.17; 95%CI = 1.25-3.76), whereas in the Aviles health area, no differences in risk were found by area of exposure. This study provides further evidence that air pollution is a moderate risk factor for lung cancer.