Enabling Sensor Technologies for the Quantitative Evaluation of Engineered Tissue
Enabling Sensor Technologies for the Quantitative Evaluation of Engineered Tissue
复制标题
利用传感器技术对工程组织进行定量评估
DOI：
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发表时间：
2007
影响因子：
3.8
通讯作者：
Anuja Choubey
中科院分区：
文献类型：
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作者：
B. Starly;Anuja Choubey
再生医学的研究需要先进的传感技术来监测和评估工程组织的质量。已经开发了几种传感方案来检测特定的分析物，使研究人员能够评估组织形态，生长和功能。除了显微镜和染色技术外，组织工程师还提供了一系列光学，化学和生物传感器技术，为他们提供了以无创或微创方式监测氧气浓度，pH值，二氧化碳和葡萄糖浓度等变量的机会。本文简要介绍了近十年来组织工程中传感器应用的核心技术和研究进展。文章最后提出了一些挑战，这些技术的进一步发展，能够真实的时间测量的组织结构，组成和功能，在体外和体内分析。
Research in regenerative medicine has necessitated the need for advanced sensing technologies to monitor and evaluate the quality of engineered tissues. Several sensing schemes have been developed to sense specific analytes that enable researchers to assess tissue morphology, growth, and function. In addition to microscopy and staining techniques, tissue engineers are presented with an array of optical, chemical, and biological sensor technologies, which provide them with an opportunity to monitor variables, such as oxygen concentration, pH value, carbon dioxide, and glucose concentration in a noninvasive or minimally invasive manner. The article presents a short description on the core technologies and research reviews on the use of sensors employed in tissue engineering over the past decade. The article concludes by presenting some of the challenges to the further development of these technologies that are capable of real time measurement of tissue structure, composition, and function both for in-vitro and in-vivo analysis.