Calcium polycarbophil, a water absorbing polymer, increases bowel movement and prevents sennoside-induced diarrhea in dogs.
Calcium polycarbophil, a water absorbing polymer, increases bowel movement and prevents sennoside-induced diarrhea in dogs.
复制标题
聚卡波非钙是一种吸水性聚合物，可促进肠蠕动并预防犬番泻苷引起的腹泻。
DOI：
--
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Z. Itoh
中科院分区：
文献类型：
--
作者：
T. Saito;T. Yamada;Y. Iwanaga;K. Morikawa;O. Nagata;H. Kato;A. Mizumoto;Z. Itoh
在狗中，与已知的泻药和抗腹泻剂相比，检查了聚卡波非钙（CP）（一种吸水性聚合物）对排便的影响，狗是一种类似于人类粪便排出的物种。CP以剂量依赖方式增加粪便次数、粪便含水量和粪便重量，但不引起腹泻。番泻苷和羧甲基纤维素钠（CMC-Na）增加粪便含水量，并在较低剂量下引起腹泻，而不是增加粪便频率。曲美布汀减少排便次数、粪便重量和粪便含水量，导致抑制而非刺激排便。在番泻苷诱导的腹泻中，洛哌丁胺和CP改善了粪便稠度，并伴有粪便水分减少和腹泻频率降低。相比之下，CMC-Na加重粪便稠度，增加粪便含水量和腹泻频率，曲美布汀除了减少粪便重量外几乎没有明显作用。我们的研究结果表明，CP在狗中具有通便和抗腹泻作用，并且不同于常规的通便剂和抗腹泻剂。CP可能是治疗特发性便秘、分泌性腹泻和肠易激综合征的合适药物，其中便秘和腹泻交替发生，并且在较少的副作用如腹泻或便秘方面占主导地位。
The effects of calcium polycarbophil (CP), a water-absorbing polymer, on bowel movement were examined in comparison with known laxatives and anti-diarrheal agents in dogs, a species that resembles humans for stool output. CP increased stool frequency, fecal water content and fecal weight in a dose-dependent manner, but did not induce diarrhea. Sennoside and carboxymethylcellulose sodium (CMC-Na) increased fecal water content and induced diarrhea at lower doses than that which enhanced stool frequency. Trimebutine decreased stool frequency, fecal weight and fecal water content, resulting in inhibition rather than stimulation of defecation. In sennoside-induced diarrhea, loperamide and CP improved stool consistency and this was accompanied by reduced fecal moisture and frequency of diarrhea. In contrast, CMC-Na aggravated stool consistency with increased fecal water content and frequency of diarrhea, and trimebutine had little noticeable effect apart from reducing fecal weight. Our results show that CP has both laxative and anti-diarrheal effects in dogs and differed from conventional laxatives and anti-diarrheal agents. CP may be a suitable agent for treatment of idiopathic constipation, secretory diarrhea and irritable bowel syndrome with alternating constipation and diarrhea and with either predominating in terms of less side effects such as diarrhea or constipation.
洛哌丁胺的止泻作用机制。
影响因子：
29.4
作者：
Schiller,LR;SantaAna,CA;Morawski,SG;Fordtran,JS
通讯作者：
Fordtran,JS