Age-related cardiac deterioration: insights from Drosophila.
Age-related cardiac deterioration: insights from Drosophila.
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DOI：
10.2741/2047
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
R. Wessells;R. Bodmer
中科院分区：
文献类型：
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作者：
R. Wessells;R. Bodmer
随着西方国家平均寿命的不断延长，老年人的医疗保健成为越来越重要的研究热点。虽然临床医生和脊椎动物研究人员经常专注于特定的年龄相关疾病，特别是神经退行性疾病，如阿尔茨海默病和帕金森病，但研究无脊椎动物遗传模型系统的研究人员已经获得了对寿命决定的全球机制的重要见解。还有一些人采用生物化学和分子方法来阐明导致老年人常见疾病（如癌症和糖尿病）的过程。在广泛关注有机体衰老和更狭隘地关注细胞功能障碍之间，是在个体器官功能水平上研究衰老。这篇综述将试图突出最近的进展，在该地区的年龄相关的器官功能退化所提供的转基因模式生物的使用，以期将这些观察到一个框架提供了更广泛的理论的衰老过程和衰老过程中的细胞功能的研究。
As the average lifespan in Western countries continues to expand, health care for the aged has become an increasingly important research focus. While clinicians and vertebrate researchers have frequently concentrated on specific age-related diseases, particularly neurodegenerative diseases such as Alzheimer's and Parkinson's Diseases, researchers working with invertebrate genetic model systems have gained important insights into global mechanisms of lifespan determination. Still others have employed biochemical and molecular approaches to elucidate processes contributing to common diseases of the elderly, such as cancer and diabetes. In between the broad focus on organismal aging and the more narrow focus on cellular dysfunction is the study of aging at the level of individual organ function. This review will attempt to highlight recent advances in the area of age-related deterioration of organ function provided by the use of transgenic model organisms, with a view toward incorporating these observations into a framework provided by both broader theories of the aging process and studies of cellular function during aging.