Chromatin remodelling comes into focus.
Chromatin remodelling comes into focus.
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DOI：
10.12688/f1000research.21933.1
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发表时间：
2020-01-01
期刊：
影响因子：
--
通讯作者：
Owen-Hughes, Tom
中科院分区：
文献类型：
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作者：
Sundaramoorthy, Ramasubramian;Owen-Hughes, Tom
ATP依赖的染色质重塑酶是一种分子机器，其作用是重新配置核小体的结构。直到最近，人们对这些酶的结构知之甚少。最近的进展表明，它们与染色质的相互作用是由ATP酶结构域，接触DNA在核小体表面上的有利位置占主导地位。与组蛋白的接触是有限的，但在调节活性中发挥重要作用。ATP酶结构域不单独起作用，而是由不同的辅助结构域和亚基侧接。新的结构表明这些亚基是如何排列在多亚基复合物中的，从而提供了一个框架，可以从中了解一个共同的马达是如何应用于不同的功能的。
ATP-dependent chromatin remodelling enzymes are molecular machines that act to reconfigure the structure of nucleosomes. Until recently, little was known about the structure of these enzymes. Recent progress has revealed that their interaction with chromatin is dominated by ATPase domains that contact DNA at favoured locations on the nucleosome surface. Contacts with histones are limited but play important roles in modulating activity. The ATPase domains do not act in isolation but are flanked by diverse accessory domains and subunits. New structures indicate how these subunits are arranged in multi-subunit complexes providing a framework from which to understand how a common motor is applied to distinct functions.