Cytomegalovirus Immunoglobulin G Antibody Is Associated With Subclinical Carotid Artery Disease Among HIV-Infected Women
Cytomegalovirus Immunoglobulin G Antibody Is Associated With Subclinical Carotid Artery Disease Among HIV-Infected Women
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DOI：
10.1093/infdis/jis276
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发表时间：
2012-06-15
影响因子：
6.4
通讯作者：
Kaplan, Robert C.
中科院分区：
文献类型：
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作者：
Parrinello, Christina M.;Sinclair, Elizabeth;Kaplan, Robert C.
背景。巨细胞病毒 (CMV) 感染与免疫激活和人类免疫缺陷病毒 (HIV) 合并感染导致的免疫缺陷加速进展有关。我们假设 CMV 与 HIV 感染成人的血管疾病有关。方法。在妇女机构间艾滋病毒研究中，我们研究了 601 名艾滋病毒感染者和 90 名未感染艾滋病毒的参与者。我们评估了 CMV 免疫球蛋白 G (IgG) 水平与颈动脉内膜中层厚度、颈动脉扩张性、杨氏弹性模量和血压的关系。根据年龄、种族/民族、吸烟、糖尿病和体重指数调整的多变量模型。结果。与未感染 HIV 的女性相比，HIV 感染女性的平均 CMV IgG 水平较高（P
Background. Cytomegalovirus (CMV) infection has been implicated in immune activation and accelerated progression of immunodeficiency from human immunodeficiency virus (HIV) coinfection. We hypothesized that CMV is associated with vascular disease in HIV-infected adults.Methods. In the Women's Interagency HIV Study, we studied 601 HIV-infected and 90 HIV-uninfected participants. We assessed the association of CMV immunoglobulin G (IgG) level with carotid artery intima-media thickness, carotid artery distensibility, Young's elastic modulus, and blood pressures. Multivariable models adjusted for age, race/ethnicity, smoking, diabetes, and body mass index.Results. Mean CMV IgG levels were higher in HIV-infected women compared with HIV-uninfected women (P