Tumor-Infiltrating CD1a+ DCs and CD8+/FoxP3+ Ratios Served as Predictors for Clinical Outcomes in Tongue Squamous Cell Carcinoma Patients
Tumor-Infiltrating CD1a+ DCs and CD8+/FoxP3+ Ratios Served as Predictors for Clinical Outcomes in Tongue Squamous Cell Carcinoma Patients
复制标题
肿瘤浸润 CD1a( ) DC 和 CD8( )/FoxP3( ) 比率可作为舌鳞状细胞癌患者临床结果的预测因子
DOI：
10.1007/s12253-019-00701-5
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发表时间：
2019-10-12
影响因子：
2.8
通讯作者：
Hu, Qin-Gang
中科院分区：
文献类型：
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作者：
Ni, Yan-Hong;Zhang, Xiao-xin;Hu, Qin-Gang
肿瘤浸润性免疫细胞参与与肿瘤的广泛串扰，并通过抑制或促进癌症生长而充当双刃剑。因此，确定肿瘤浸润免疫细胞的密度和预后价值将为癌症治疗提供有价值的提示。本研究检测了153例舌鳞状细胞癌（TSCC）组织中肿瘤炎性浸润密度和肿瘤浸润免疫细胞（包括CD3+、CD4+、CD8+、FoxP3 + T细胞和CD1a+树突状细胞（DCs））的数量。高炎性细胞浸润与较好的总生存期（OS）和无病生存期（DFS）相关。CD3（+）、CD4（+）、FoxP3（+）、CD1a（+）细胞数与肿瘤分化程度相关（P
Tumor-infiltrating immune cells engage in an extensive crosstalk with tumors and act as two-edged swords by inhibiting or promoting cancer growth. Therefore, identifying the density and prognostic values of tumor-infiltrating immune cells will provide valuable tips for cancer treatments. In this study, we identified the density of tumor inflammatory infiltrates and the number of tumor-infiltrating immune cells, including CD3(+), CD4(+), CD8(+), FoxP3(+) T cells and CD1a(+) dendritic cells (DCs) in 153 tongue squamous cell carcinomas (TSCC). High inflammatory cell infiltration was associated with better overall survival (OS) and disease free survival (DFS). Moreover, the number of CD3(+), CD4(+), FoxP3(+) and CD1a(+) cells were associated with tumor differentiation (P