Highly Modified Lanostane Triterpenes from the Wood-Rot Basidiomycete Ganoderma colossus: Comparative Chemical Investigations of Natural and Artificially Cultivated Fruiting Bodies and Mycelial Cultures
Highly Modified Lanostane Triterpenes from the Wood-Rot Basidiomycete Ganoderma colossus: Comparative Chemical Investigations of Natural and Artificially Cultivated Fruiting Bodies and Mycelial Cultures
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来自木腐担子菌灵芝的高度改性羊毛甾烷三萜：天然和人工培养的子实体和菌丝体培养物的比较化学研究
DOI：
10.1021/acs.jnatprod.9b00947
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发表时间：
2020
影响因子：
5.1
通讯作者：
Mori Seiji
中科院分区：
文献类型：
--
作者：
Isaka Masahiko;Chinthanom Panida;Choeyklin Rattaket;Thummarukcharoen Tuksaporn;Rachtawee Pranee;Sappan Malipan;Srichomthong Kitlada;Fujii Ryoma;Kawashima Kyohei;Mori Seiji
本文对木腐菌灵芝进行了化学研究。对天然子实体、人工栽培子实体和菌丝体培养物的比较分析导致总共分离出13种新的高度修饰的羊毛甾烷、灵芝素A-H（1-8）和灵芝内酯T-X（9-13）以及23种已知化合物（14-36）。在三种不同状态的真菌材料中，相同的化合物有明显的重叠。其中Ganoclusin D（4）对恶性疟原虫K1（多药耐药株）的IC_（50）值为2.4 μM，对Vero细胞无细胞毒性。
The wood-rot basidiomyceteGanoderma colossushas been chemically investigated. Comparative analyses of the natural fruiting body, artificially cultivated fruiting bodies, and mycelial cultures resulted in the isolation, in total, of 13 new highly modified lanostanes, ganocolossusins A–H (1–8) and ganodermalactones T–X (9–13), together with 23 known compounds (14–36). There were significant overlaps of the same compounds among the three different states of the fungal materials. Ganocolossusin D (4) displayed the most potent antimalarial activity againstPlasmodium falciparumK1 (multi-drug-resistant strain) with an IC50value of 2.4 μM, while it was noncytotoxic to Vero cells at 50 μg/mL.