Eradication of Helicobacter pylori increases the incidence of hyperlipidaemia and obesity in peptic ulcer patients
Eradication of Helicobacter pylori increases the incidence of hyperlipidaemia and obesity in peptic ulcer patients
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DOI：
10.1016/j.dld.2004.07.017
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发表时间：
2005-01-01
影响因子：
4.5
通讯作者：
Haruma, K
中科院分区：
文献类型：
--
作者：
Kamada, T;Hata, J;Haruma, K
背景。根除幽门螺杆菌可改善消化性溃疡患者的临床症状和生活质量。目的。探讨根除幽门螺杆菌对消化性溃疡患者体重指数和高脂血症发生率的影响。患者和方法。研究人群包括 50 名患者（42 名男性，8 名女性；平均年龄 51 岁；28 例胃溃疡，22 例十二指肠溃疡），他们在接受根除治疗之前和之后 1 年接受了身体和血液检查，以及 100 名性别和年龄匹配的对照受试者。治疗前和治疗后 1 年测量体重指数、总胆固醇和甘油三酯。结果。根除治疗组的体重指数（根除前为 22.7+/-2.5 kg/m(2)，根除后为 23.6+/-2.6 kg/m(2)，p < 0.01）、血清总胆固醇（204.1+/-33.2 mg/dL 与 221.2+/-38.8 mg/dL，p < 0.01）和甘油三酯显着增加。此外，根除治疗组的高胆固醇血症发生率显着增加（30% vs 58%，p
Background. Eradication of Helicobacter pylori improves clinical symptoms and quality of life in patients with peptic ulcer.Aim. To investigate the effect of eradication of H. pylori on body mass index and incidence of hyperlipidaemia in patients with peptic ulcer.Patients and methods. The Study population comprised 50 patients (42 men, 8 women; mean age, 51 years; 28 gastric ulcer, 22 duodenal ulcer) who underwent physical and blood examination before and 1 year after undergoing eradication therapy and 100 sex- and age-matched control subjects. Body mass index, total cholesterol and triglyceride were measured before and 1 year after therapy.Results. The eradication therapy group showed a significant increase in body mass index (22.7+/-2.5 kg/m(2) before eradication versus 23.6+/-2.6 kg/m(2) after eradication, p < 0.01), serum total cholesterol (204.1+/-33.2 mg/dL versus 221.2+/-38.8 mg/dL, p < 0.01), and triglyceride. Additionally, the eradication therapy group showed a significant increase in the incidence of hypercholesterolemia (30% versus 58%, p