Exploring the Role of Transglutaminase in Patients with Glioblastoma: Current Perspectives.
Exploring the Role of Transglutaminase in Patients with Glioblastoma: Current Perspectives.
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DOI：
10.2147/ott.s329262
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发表时间：
2022
影响因子：
4
通讯作者：
Cerione RA
中科院分区：
文献类型：
--
作者：
Katt WP;Aplin C;Cerione RA
组织转谷氨酰胺酶（tTG）是一种相当独特的gtp结合/蛋白质交联酶，已被证明在影响正常生理和疾病状态的许多细胞过程中发挥重要作用。这在侵袭性脑肿瘤，如胶质母细胞瘤的情况下尤其如此。近年来，tTG在癌症生存和进展中发挥的多种作用引起了人们对使用tTG作为治疗靶点的极大兴趣。在这篇综述中，我们简要介绍了转谷氨酰胺酶家族，然后讨论了tTG所表现出的主要生化活性，重点讨论了它在胶质母细胞瘤进展中的作用。最后，我们考虑了目前可能最终产生临床影响的tTG靶标方法。
Tissue transglutaminase (tTG) is a rather unique GTP-binding/protein crosslinking enzyme that has been shown to play important roles in a number of cellular processes that impact both normal physiology and disease states. This is especially the case in the context of aggressive brain tumors, such as glioblastoma. The diverse roles played by tTG in cancer survival and progression have led to significant interest in recent years in using tTG as a therapeutic target. In this review, we provide a brief overview of the transglutaminase family, and then discuss the primary biochemical activities exhibited by tTG with an emphasis on the role it plays in glioblastoma progression. Finally, we consider current approaches to target tTG which might eventually have clinical impact.