Neural dynamics of in vitro cortical networks reflects experienced temporal patterns
Neural dynamics of in vitro cortical networks reflects experienced temporal patterns
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DOI：
10.1038/nn.2579
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发表时间：
2010-08-01
影响因子：
25
通讯作者：
Buonomano, Dean V.
中科院分区：
文献类型：
--
作者：
Johnson, Hope A.;Goel, Anubhuthi;Buonomano, Dean V.
学习最终依赖于神经微电路活动流程的变化。神经动力学的可塑性与时间信息的处理特别相关。对培养的大鼠皮层网络的慢性刺激揭示了神经动力学的经验依赖性可塑性。我们观察到活动时间结构的变化反映了训练期间使用的时间间隔，这表明皮层回路本质上能够在短时间尺度上进行时间处理。
Learning ultimately relies on changes in the flow of activity in neural microcircuits. The plasticity of neural dynamics is particularly relevant for the processing of temporal information. Chronic stimulation of cultured rat cortical networks revealed experience-dependent plasticity in neural dynamics. We observed changes in the temporal structure of activity that reflected the intervals used during training, suggesting that cortical circuits are inherently capable of temporal processing on short timescales.