Fly photoreceptor synapses: their development, evolution, and plasticity.
Fly photoreceptor synapses: their development, evolution, and plasticity.
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苍蝇感光突触：它们的发育、进化和可塑性。
DOI：
10.1002/neu.480200503
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Meinertzhagen,IA
中科院分区：
文献类型：
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作者：
Meinertzhagen,IA
综述了近年来对果蝇、蝇类和果蝇第一视神经丛感光末梢突触的研究进展。传入突触接触具有统一的尺寸；它们有一个突触后四分体，具有 P 面颗粒的膜组织，类似于其他抑制性突触。在突触发生过程中，通过在受体末端选择性、连续地增加已识别的突触后元件，逐渐形成此类接触位点的分布式群体。该突触的比较解剖学表明，在其系统发育过程中，也从祖先的二元体中添加了元素。所有细胞均与其他双翅目物种的细胞同源。突触位点的数量由突触前和突触后细胞调节，与其细胞表面成比例；受体末端（在突变果蝇中获得）的独立大小增加会导致其突触数量的增加。然而，突触位点的数量随着年龄的增长而减少，同时剩余突触位点的大小也随之增加。传入和反馈光感受器突触都会发生这种情况。最后，站点的数量随着视觉体验的变化而变化；成年早期黑暗饲养后的反馈突触频率比视觉体验后的突触频率更高。
Recent studies are reviewed on the synapses of photoreceptor terminals in the first optic neuropile of the flies,MuscaandDrosophila. Afferent synaptic contacts are of uniform dimensions; they have a postsynaptic tetrad with a membrane organization of P‐face particles, resembling other inhibitory synapses. A distributed population of such contact sites forms progressively during synaptogenesis by the selective, sequential accretion of identified postsynaptic elements at the receptor terminal. The comparative anatomy of this synapse indicates that elements have also been added during its phylogeny from an ancestral dyad. All cells are homologs of those in other species of Diptera. The number of synaptic sites is regulated by both pre‐ and postsynaptic cells, in proportion to their cell surfaces; an independent size increase in the receptor terminals (procured in theDrosophilamutantgigas) produces an increase in their synaptic population. The number of sites declines with age, however, accompanied by an increase in size of those synaptic sites remaining; this occurs for both afferent and feedback photoreceptor synapses. Lastly, the number of sites changes with visual experience; the frequency of feedback synapses is larger following dark rearing during early adult life than following visual experience.