Analysis of the control mechanism of lung cancer of caspase recruitment domain-containing protein 9 and myeloid-derived suppressor cell in Lewis lung cancer mice model
Analysis of the control mechanism of lung cancer of caspase recruitment domain-containing protein 9 and myeloid-derived suppressor cell in Lewis lung cancer mice model
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Lewis肺癌小鼠模型中caspase募集结构域蛋白9与髓源性抑制细胞对肺癌的调控机制分析
DOI：
10.1016/j.sjbs.2019.09.024
复制
发表时间：
2019-09
影响因子：
4.4
通讯作者：
Fan Xiaowu
中科院分区：
文献类型：
--
作者：
Wu Xiaowei;Li Fan;Deng Yu;Fan Xiaowu
本研究旨在通过刘易斯肺癌小鼠模型，探讨caspase募集结构域蛋白9（CARD 9）和免疫抑制细胞髓源性抑制细胞（MDSC）作用下肺癌发生的内在机制。本研究以小鼠为研究对象，通过mRNA表达水平、肿瘤细胞HE染色、电镜等实验方法，研究CARD 9和免疫抑制细胞MDSCs在肺癌中的作用机制。结果表明，CARD 9通过控制免疫抑制细胞MDSC及其下游产物吲哚胺2，3-双加氧酶（IDO）的工作状态来调控肺癌。本研究证实了CARD 9-MDSCs-NF-KB-IDO在肿瘤环境下对MDSC的肿瘤调控机制。综上所述，CARD 9和免疫抑制细胞MDSC在肺癌中的作用机制是通过控制下游产物IDO来达到肿瘤控制的目的。在研究过程中还存在一些不足之处，但研究结果仍为今后的研究提供了一定的指导。因此，这是一个具有现实意义的研究课题。
The purpose of this study was to explore the internal mechanism of lung cancer under the action of caspase recruitment domain-containing protein 9 (CARD9) and immunosuppressive cells myeloid-derived suppressor cells (MDSCs) in the Lewis lung cancer mice model. In this research, mice were selected as research objects, and the mechanism of CARD9 and immunosuppressive cells MDSCs in lung cancer was studied by experimental methods such as mRNA expression level, HE staining of tumor cells, and electron microscopy. The results showed that CARD9 regulated lung cancer by controlling the working state of immunosuppressive cells MDSCs and its downstream product indoleamine 2, 3-dioxygenase (IDO). The study confirmed the tumor regulatory mechanism of CARD9-MDSCs-NF-KB-IDO in MDSCs under tumor environment. In summary, the mechanism of CARD9 and immunosuppressive cells MDSCs in lung cancer was to achieve the goal of tumor control through the control of downstream product IDO. There are still some shortcomings in the research process, but the research results still provide some guidance for future research. Therefore, it is a research topic with practical significance.
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