A novel "Integrated Biomarker Response" calculation based on reference deviation concept
A novel "Integrated Biomarker Response" calculation based on reference deviation concept
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DOI：
10.1007/s11356-012-1359-1
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发表时间：
2013-05-01
影响因子：
5.8
通讯作者：
Porcher, Jean-Marc
中科院分区：
文献类型：
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作者：
Sanchez, Wilfried;Burgeot, Thierry;Porcher, Jean-Marc
多生物标志物方法用于评估生态系统健康并确定环境压力对生物体的影响。然而，环境管理者对大型数据集的探索对该工具的监管应用提出了重大挑战。开发了几种综合工具来总结生物标志物反应。本文的目的是更新 Beliaeff 和 Burgeot (Environ Toxicol Chem 21:1316-1322, 2002) 描述的“综合生物反应”(IBR) 的计算，以避免该综合工具的弱点。在本文中，提出了一种基于参考偏差概念的新型指数，名为“综合生物反应版本2”。与 IBR 一样，它可以清楚地区分采样点，但根据生物标志物反应的上调和下调，可以观察到污染地点的一些差异。这种新颖的工具不仅可以用于大规模监测，还可以用于上游/下游研究中整合多生物标志物反应。
Multi-biomarker approaches are used to assess ecosystem health and identify impacts of environmental stress on organisms. However, exploration of large datasets by environmental managers represents a major challenge for regulatory application of this tool. Several integrative tools were developed to summarize biomarker responses. The aim of the present paper is to update calculation of the "Integrated Biological Response" (IBR) described by Beliaeff and Burgeot (Environ Toxicol Chem 21:1316-1322, 2002) to avoid weaknesses of this integrative tool. In the present paper, a novel index named "Integrated Biological Responses version 2" based on the reference deviation concept is presented. It allows a clear discrimination of sampling sites as for the IBR, but several differences are observed for contaminated sites according to up- and downregulation of biomarker responses. This novel tool could be used to integrate multi-biomarker responses not only in large-scale monitoring but also in upstream/downstream investigations.