Genevestigator v3: a reference expression database for the meta-analysis of transcriptomes.
Genevestigator v3: a reference expression database for the meta-analysis of transcriptomes.
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DOI：
10.1155/2008/420747
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发表时间：
2008
影响因子：
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通讯作者：
Zimmermann P
中科院分区：
文献类型：
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作者：
Hruz T;Laule O;Szabo G;Wessendorp F;Bleuler S;Oertle L;Widmayer P;Gruissem W;Zimmermann P
基于Web的软件工具Genevestigator为生物学家提供了强大的工具，以探索各种生物背景下的基因表达。然而，它的第一个版本受到系统架构的扩展能力，多生物体数据存储和分析能力以及计算密集型分析方法的可用性的限制。Genevestigator V3是一种新型的荟萃分析系统，它使用客户端/服务器架构，对几种生物的微阵列数据进行大规模人工管理和质量控制，以及对小鼠和拟南芥的途径数据进行管理，从而产生了新的算法和软件开发。除了改进的查询功能外，Genevestigator V3还提供了新的工具来分析许多不同背景下的基因表达，识别生物标志物基因，将基因聚类到表达模块中，并在代谢和调控网络的背景下对表达反应进行建模。 作为一个具有用户友好工具的参考表达数据库，Genevestigator V3有助于发现研究和假设验证。
The Web-based software tool Genevestigator provides powerful tools for biologists to explore gene expression across a wide variety of biological contexts. Its first releases, however, were limited by the scaling ability of the system architecture, multiorganism data storage and analysis capability, and availability of computationally intensive analysis methods. Genevestigator V3 is a novel meta-analysis system resulting from new algorithmic and software development using a client/server architecture, large-scale manual curation and quality control of microarray data for several organisms, and curation of pathway data for mouse and Arabidopsis. In addition to improved querying features, Genevestigator V3 provides new tools to analyze the expression of genes in many different contexts, to identify biomarker genes, to cluster genes into expression modules, and to model expression responses in the context of metabolic and regulatory networks. Being a reference expression database with user-friendly tools, Genevestigator V3 facilitates discovery research and hypothesis validation.