Inhibitory actions of genistein in human breast cancer (MCF-7) cells
Inhibitory actions of genistein in human breast cancer (MCF-7) cells
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DOI：
10.1016/s0925-4439(03)00082-6
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发表时间：
2003-07-14
影响因子：
6.2
通讯作者：
Wong, MS
中科院分区：
文献类型：
--
作者：
Chen, WF;Huang, MH;Wong, MS
染料木黄酮是一种天然的异黄酮植物雌激素，被认为是大豆中的活性成分，具有预防乳腺癌的特性。参与其癌症预防特性的分子机制尚未完全了解。本研究旨在探讨染料木黄酮对乳腺癌MCF-7细胞的抑制作用及其机制。50和100 μ M的金雀异黄素可显著抑制MCF-7细胞在G2/M期的生长（P
Genistein, a natural isoflavanoid phytoestrogen, is thought to be the active ingredient in soy that possesses breast cancer preventive properties. The molecular mechanisms that are involved in its cancer preventive properties have not been completely understood. The present study is designed to investigate the mechanism involved in the inhibitory action of genistein in MCF-7 cells. Genistein at 50 and 100 muM significantly arrested the growth of MCF-7 cells at G2/M phase (P