Preserved reticular neuronal activity during selective delivery of supra-clinical isoflurane concentrations to brain in goats and its association with spontaneous movement.
Preserved reticular neuronal activity during selective delivery of supra-clinical isoflurane concentrations to brain in goats and its association with spontaneous movement.
复制标题
在选择性地将超临床异氟醚浓度递送至山羊大脑期间保留的网状神经元活动及其与自发运动的关联。
DOI：
10.1016/j.neulet.2003.12.024
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Atherley,RichardJ
中科院分区：
文献类型：
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作者：
Antognini,JosephF;Jinks,StevenL;Carstens,EarlE;Atherley,RichardJ
我们以前已经观察到，当超临床浓度的异氟醚选择性地输送到原位山羊大脑时，自发运动。我们目前研究了中脑网状结构（MRF）中的神经元在这种递送过程中是否保持活跃。异氟烷（5.1±1.6%）选择性输送到山羊颅循环，而躯干异氟烷减少到0.2-0.3%。在高颅/低躯干异氟醚组合时，自发运动通常包括跑步运动、僵硬和抽搐。在6只山羊中记录的17个MRF神经元表现出高自发放电（33±20 Hz），尽管存在等电脑电图。我们的结论是，一些MRF神经元对异氟醚的抑制作用有抵抗力，可能有助于观察到的自发运动。
We have previously observed spontaneous movement when supra-clinical concentrations of isoflurane were selectively delivered to the in situ goat brain. We presently examined whether neurons in the midbrain reticular formation (MRF) remained active during such delivery. Isoflurane (5.1±1.6%) was selectively delivered to the goat cranial circulation while the torso isoflurane was decreased to 0.2–0.3%. At the high cranial/low torso isoflurane combination, spontaneous movement occurred that usually consisted of running motions, stiffening and twitching. Seventeen MRF neurons recorded in six goats exhibited high spontaneous firing (33±20 Hz) despite the presence of an isoelectric electroencephalogram. We conclude that some MRF neurons are resistant to the depressant effect of isoflurane, and may contribute to the observed spontaneous movement.