Pretreatment Inflammatory Indexes as Prognostic Predictors of Survival in Patients Suffering From Synovial Sarcoma
Pretreatment Inflammatory Indexes as Prognostic Predictors of Survival in Patients Suffering From Synovial Sarcoma
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DOI：
10.3389/fonc.2019.00955
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发表时间：
2019-09-24
影响因子：
4.7
通讯作者：
Ma, Xuelei
中科院分区：
文献类型：
--
作者：
Cheng, Yuan;Mo, Fei;Ma, Xuelei
背景：炎症指标已被认为是各种类型癌症的重要预后因素。本研究旨在评价中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、淋巴细胞与单核细胞比值（LMR）在滑膜肉瘤（SS）患者中的预后价值。方法：收集2006-2017年诊断为SS的患者103例，根据受试者工作特征曲线分析分为高、低NLR组、PLR组和LMR组。收集临床变量资料进行单因素和多因素分析。采用Kaplan-Meier法分析SS患者的OS和PFS，采用log-rank检验评价显著性。结果：NLR、PLR、LMR的最佳临界值分别为2.70、154.99、4.16。单因素分析确定切除手术、远处转移、NLR、PLR和LMR是无进展生存期（PFS）和总生存期（OS）的潜在预测因素。在多变量分析中，NLR是OS的独立预测因子（HR 5.074, 95% CI 1.200-21.463, p = 0.027）。切除手术、转移和LMR是PFS的独立预测因素（HR 5.328, p = 0.017; HR 3.114, p = 0.04; HR 0.202, p = 0.025）。结论：手术切除、远处转移、NLR和LMR是滑膜肉瘤患者PFS和OS的独立预后因素。手术作为除放疗和化疗外的有效治疗策略，可显著延长滑膜患者的生存期。这些炎症生物标志物的临床应用应在更大的样本量研究中得到验证。
Background: Inflammatory indexes have been considered as important prognostic factors in various types of cancers. This study aimed to evaluate prognostic values of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR) in patients with synovial sarcoma (SS).Methods: One hundred and three patients diagnosed with SS were collected during 2006-2017 and divided into high or low NLR, PLR, and LMR groups based on receiver operating characteristic curve analysis. Data of clinical variables were collected for univariate and multivariate analyses. The Kaplan-Meier method was used to analyze OS and PFS of SS patients and significance was evaluated by the log-rank test.Results: The optimal cut-off values of NLR, PLR, and LMR were 2.70, 154.99, and 4.16, respectively. Univariate analyses identified resection surgery, distant metastasis, NLR, PLR, and LMR as the potential predictors of progression-free survival (PFS) and overall survival (OS). In the multivariate analyses, NLR was independent predictors for OS (HR 5.074, 95% CI 1.200-21.463, p = 0.027). Resection surgery, metastasis and LMR was independent predictors for PFS (HR 5.328, p = 0.017; HR 3.114, p = 0.04 and HR 0.202, p = 0.025, respectively).Conclusion: Resection surgery, distant metastasis, NLR, and LMR were independent prognostic factors of PFS and OS in patients with synovial sarcoma. Surgery as an effective treatment strategy, other than radiotherapy and chemotherapy, can significantly prolong survival of synovial patients. Clinical utility of these inflammatory biomarkers should be validated in a larger sample size study.