Vitamin D Is a Major Determinant of Bone Mineral Density at School Age
Vitamin D Is a Major Determinant of Bone Mineral Density at School Age
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DOI：
10.1371/journal.pone.0040090
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发表时间：
2012-07-02
期刊：
影响因子：
3.7
通讯作者：
Makitie, Outi
中科院分区：
文献类型：
--
作者：
Pekkinen, Minna;Viljakainen, Heli;Makitie, Outi
背景：儿童维生素D缺乏可能对骨骼造成长期后果，因为维生素D影响钙吸收、骨矿化和骨量获得。方法/主要研究结果：这项以学校为基础的研究调查了195名芬兰儿童和青少年(年龄7-19岁)的维生素D状况及其与维生素D摄入量和骨健康的关系。评估患者的临床特征、体力活动和膳食维生素D摄入量。采集血样和尿样，测定血清25-羟基维生素D(25-OHD)和钙稳态的其他参数。采用双能X线骨密度仪(DXA)测量骨密度(BMD)和体成分。总共有71%的受试者维生素D不足(25-OHD
Background: Vitamin D insufficiency in children may have long-term skeletal consequences as vitamin D affects calcium absorption, bone mineralization and bone mass attainment.Methodology/Principal Findings: This school-based study investigated vitamin D status and its association with vitamin D intake and bone health in 195 Finnish children and adolescents (age range 7-19 years). Clinical characteristics, physical activity and dietary vitamin D intake were evaluated. Blood and urine samples were collected for serum 25-hydroxyvitamin D (25-OHD) and other parameters of calcium homeostasis. Bone mineral density (BMD) and body composition were measured with dual-energy X-ray absorptiometry (DXA). Altogether 71% of the subjects were vitamin D insufficient (25-OHD