IMPAIRED INTESTINAL BARRIER FUNCTION MEASURED BY DIFFERENTLY SIZED POLYETHYLENE GLYCOLS IN PATIENTS WITH CHRONIC-RENAL-FAILURE
IMPAIRED INTESTINAL BARRIER FUNCTION MEASURED BY DIFFERENTLY SIZED POLYETHYLENE GLYCOLS IN PATIENTS WITH CHRONIC-RENAL-FAILURE
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DOI：
10.1136/gut.32.7.754
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发表时间：
1991-07-01
期刊：
影响因子：
24.5
通讯作者：
DENNEBERG, T
中科院分区：
文献类型：
--
作者：
MAGNUSSON, M;MAGNUSSON, KE;DENNEBERG, T
肠粘膜作为吸收营养的部位，以及作为肠腔中潜在有害物质的重要屏障，发挥着重要作用。对尿毒症患者肠粘膜的通透性知之甚少。在9名慢性肾衰竭患者（24小时内生肌酐清除率5-27 ml/min）中研究了不同大小聚乙二醇（PEG;范围326-1254道尔顿）的肠道渗透性。尿毒症患者24小时尿中PEG的最大回收率降低，但在这些患者中发现较大的PEG相对多于较小的PEG。结果表明，减少尿回收的PEG引起的肾功能不全，但也相对增加肠通透性较大的PEG在尿毒症患者。
The intestinal mucosa plays a fundamental role as the site for absorption of nutrients, and as an important barrier from potentially harmful agents in the intestinal lumen. Little is known of the permeability properties of the intestinal mucosa in uraemic patients. The intestinal permeability to differently sized polyethylene glycols (PEGs; range 326-1254 daltons) was studied in nine patients with chronic renal failure (24 hour endogenous creatinine clearance 5-27 ml/minute). The maximum 24 hour urinary recovery of PEGs was decreased in the uraemic patients but relatively more of the larger than the smaller PEGs were found in these patients. The results suggest a reduced urinary recovery of PEGs caused by renal dysfunction but also a relatively increased intestinal permeability to larger PEGs in the uraemic patients.