Distinct modulatory effects of satiety and sibutramine on brain responses to food images in humans: a double dissociation across hypothalamus, amygdala, and ventral striatum.
Distinct modulatory effects of satiety and sibutramine on brain responses to food images in humans: a double dissociation across hypothalamus, amygdala, and ventral striatum.
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DOI：
10.1523/jneurosci.3323-10.2010
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发表时间：
2010-10-27
期刊：
影响因子：
--
通讯作者：
Bullmore ET
中科院分区：
文献类型：
--
作者：
Fletcher PC;Napolitano A;Skeggs A;Miller SR;Delafont B;Cambridge VC;de Wit S;Nathan PJ;Brooke A;O'Rahilly S;Farooqi IS;Bullmore ET
我们使用功能磁共振成像来探索超重人类对食物图像的大脑反应，独立地检查了扫描前一餐(饱腹感)和抗肥胖药西布曲明的影响，西布曲明是一种血清素和去甲肾上腺素再摄取抑制剂。我们在杏仁核、下丘脑和腹侧纹状体发现了对这些操作的显著不同反应。与低卡路里食物相比，每个区域对高卡路里食物都有特别的反应。然而，腹侧纹状体反应被饱腹感减弱(但不受西布曲明的影响)，而下丘脑和杏仁核的反应被药物减弱，但不受饱腹感的影响。对区域相互作用的直接评估证实了这种双重分离的重要性。我们通过确定它们是否可以预测饮食行为和体重变化，更详细地探索了地区性反应。我们观察到，在不同的区域，药物和饱腹感诱导的调节的个体特定幅度与这两个变量相关：西布曲明诱导的下丘脑反应调节与药物对体重和随后测量的自由进食的影响相关。饱腹感引起的纹状体反应的调节也与随后的随意进食有关。这些结果表明，下丘脑和杏仁核在控制摄食方面起着不同于腹侧纹状体的作用。此外，它们还支持西布曲明对大脑功能的区域性影响，西布曲明通过这种作用发挥临床效果。
We used fMRI to explore brain responses to food images in overweight humans, examining independently the impact of a pre-scan meal (“satiety”) and the anti-obesity drug sibutramine, a serotonin and noradrenaline reuptake inhibitor. We identified significantly different responses to these manipulations in amygdala, hypothalamus and ventral striatum. Each region was specifically responsive to high calorie compared to low calorie food images. However, the ventral striatal response was attenuated by satiety (but unaffected by sibutramine) while the hypothalamic and amygdala responses were attenuated by drug but unaffected by satiety. Direct assessment of regional interactions confirmed the significance of this double dissociation. We explored the regional responses in greater detail by determining whether they were predictive of eating behaviour and weight change. We observed that across the different regions, the individual-specific magnitude of drug- and satiety-induced modulation was associated with both variables: the sibutramine-induced modulation of the hypothalamic response was correlated with the drug’s impact on both weight and subsequently-measured ad libitum eating. The satiety-induced modulation of striatal response also correlated with subsequent ad lib eating. These results suggest that hypothalamus and amygdala have roles in the control of food intake that are distinct from those of ventral striatum. Furthermore, they support a regionally-specific effect on brain function through which sibutramine exerts its clinical effect.