Intracavitary ultrasound phased arrays for prostate thermal therapies:: MRI compatibility and in vivo testing
Intracavitary ultrasound phased arrays for prostate thermal therapies:: MRI compatibility and in vivo testing
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DOI：
10.1118/1.598450
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发表时间：
1998-12-01
期刊：
影响因子：
3.8
通讯作者：
Hynynen, K
中科院分区：
文献类型：
--
作者：
Hutchinson, EB;Hynynen, K
为探讨经直肠超声用于前列腺癌和良性前列腺增生症热疗的可行性，设计并制作了与MRI兼容的62单元线性相控阵。在该阵列的设计中使用了在先前研究中开发的非周期设计技术，该技术通过使用大小不等的元件的优化随机分布来降低栅瓣电平。在该阵列中使用的元件尺寸被选择成对由阵列非周期性确定的栅瓣电平和由宽厚比确定的阵列效率都有利。在体兔大腿肌肉加热实验中，利用MRI温度监测对该阵列的加热能力和MRT兼容性进行了测试。该阵列在体内产生了治疗温度升高，深度为3-6厘米，轴向位置距离中心轴最多3厘米，并通过电子扫描单个病灶增加了加热体积的大小。这种阵列用于超声手术的能力是通过使用短而高功率的超声波在体内产生坏死组织病变来证明的。该阵列用于热疗的能力通过诱导较长时间暴露的治疗温度升高而得到证明。基于这种阵列的声学和加热性能，它有可能在临床上用于将热疗输送到前列腺和靠近体腔的其他靶区。(C)1998年美国医学物理学家协会。[S0094-2405(98)01812-4]。
A 62 element MRI-compatible linear phased array was designed and constructed to investigate the feasibility of using transrectal ultrasound for the thermal therapeutic treatment of prostate cancer and benign prostatic hyperplasia. An aperiodic design technique developed in a previous study was used in the design of this array, which resulted in reduced grating lobe levels by using an optimized random distribution of unequally sized elements. The element sizes used in this array were selected to be favorable for both grating lobe levels as determined by array aperiodicity and array efficiency as determined by width to thickness ratios. The heating capabilities and MRT compatibility of the array were tested with in vivo rabbit thigh muscle heating experiments using MRI temperature monitoring. The array produced therapeutic temperature elevations in vivo at depths of 3-6 cm and axial locations up to 3 cm off the central axis and increased the size of the heated volume with electronic scanning of a single focus. The ability of this array to be used for ultrasound surgery was demonstrated by creating necrosed tissue lesions in vivo using short high-power sonications. The ability of the array to be used for hyperthermia was demonstrated by inducing therapeutic temperature elevations for longer exposures. Based on the acoustic and heating performance of this array, it has the potential to be clinically useful for delivering thermal therapies to the prostate and other target volumes close to body cavities. (C) 1998 American Association of Physicists in Medicine. [S0094-2405(98)01812-4].