Evaluating the use of a portable ultrasound machine to quantify intima-media thickness and flow-mediated dilation: Agreement between measurements from two ultrasound machines
Evaluating the use of a portable ultrasound machine to quantify intima-media thickness and flow-mediated dilation: Agreement between measurements from two ultrasound machines
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DOI：
10.1016/j.ultrasmedbio.2006.05.009
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发表时间：
2006-09-01
影响因子：
2.9
通讯作者：
Raitakari, Olu T.
中科院分区：
文献类型：
--
作者：
Magnussen, Costan G.;Fryer, Jayne;Raitakari, Olu T.
血流介导的扩张（FMD）和颈总动脉内膜中层厚度（CIMT）是心血管疾病的中间终点。本研究的目的是确定便携式超声机是否能够有效测量FMD和CIMT相比，基于临床的机器在类似的条件下。用便携式和临床用血管造影仪对23例表面健康的青年人进行了血管造影。分析显示，两台机器之间的最大CIMT测量结果高度一致（平均差异[MD] = -0.025 mm，一致性限[LOA] =-0.080，0.029 mm），平均CIMT（MD = 0.001 mm，LOA =-0.065，0.065 mm）和FMD测量肱动脉直径（基线MD = 0.199 mm，LOA =-0.210，0.608 mm，最大MD = 0.218 mm，LOA =-0.162，0.597 mm）。发现%FMD测量值的合理一致性（MD = 0.27%，LOA =-4.91，5.44%）。最大CIMT（5.0%）、平均CIMT（4.3%）、基线（6.3%）和最大（5.4%）肱动脉直径和%FMD（30.1%）的机器内变异系数结果与正常受试者内变异相当。我们的结论是，便携式超声机可以提供FMD和CIMT的测量是高度可比的测量从一个基于临床的机器在类似的临床条件下。
Flow-mediated dilation (FMD) and common carotid intima-media thickness (CIMT) are intermediate endpoints for cardiovascular disease. The purpose of this study was to determine whether a portable ultrasound machine was capable of valid measurements of FMD and CIMT compared with a clinic-based machine under similar conditions. Vascular images were taken on 23 apparently healthy young adults with the portable type and clinic type instruments. The analyses revealed a high level of agreement between the two machines for measurements of maximum CIMT (mean difference [MD] = -0.025 mm, limits of agreement [LOA] = -0.080, 0.029 mm), mean CIMT (MD = 0.001 mm, LOA = -0.065, 0.065 mm) and FMD measures of brachial diameter (baseline MD = 0.199 mm, LOA = -0.210, 0.608 mm, maximum MD = 0.218 mm, LOA = -0.162, 0.597 mm). Reasonable agreement was found for %FMD measurements (MD = 0.27%, LOA = -4.91, 5.44%). The within-machine coefficient of variation results for maximum CIMT (5.0%), mean CIMT (4.3%), baseline (6.3%) and maximum (5.4%) brachial diameter and %FMD (30.1%) were comparable with normal within-subject variation. We conclude that the portable ultrasound machine can provide measurements of FMD and CIMT that are highly comparable with measurements obtained from a clinic-based machine under similar clinical conditions.