Growth rate of lung cancer recognized as small solid nodule on initial CT findings
Growth rate of lung cancer recognized as small solid nodule on initial CT findings
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DOI：
10.1016/j.ejrad.2011.06.032
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发表时间：
2012-04-01
影响因子：
3.3
通讯作者：
Yamada, Kouzo
中科院分区：
文献类型：
--
作者：
Mikita, Kei;Saito, Haruhiro;Yamada, Kouzo
前言：研究CT表现为小实性结节的肺癌的特点，确定合适的随访时间，以鉴别良恶性肿瘤。方法：分析34例CT表现为小实性结节的肺癌手术切除患者的临床资料。结果：VDT分为：(1)缓慢生长组(SGG)，VDT>700天；(2)快速生长组，VDT<700天。中位VDT：SGG组为1083天，RGG组为256天(p<；0.01)。SGG的中位随访时间为1218天，RGG的中位随访时间为179天。随访时间差异有统计学意义(p<；0.01)。术前薄层CT(TSCT)表现与病理结果无统计学差异。RGG包括了更多有吸烟史的患者。RGG的CT表现倾向于显示基础肺野的改变，如肺气肿、肺纤维化等。结论：肺癌在最初的CT表现上表现为小的实性结节，生长较快，但也有部分病例表现为生长缓慢。这些病例需要两年以上的随访，才有可能诊断。我们得出的结论是，合适的最长随访时间为三年。(C)2011爱思唯尔爱尔兰有限公司。保留所有权利。
Introduction: To study the characteristics of lung cancer, appearing as small solid nodules on initial computed tomography (CT) findings, and to determine an appropriate follow-up duration so as to differentiate between malignancy and benign tumor.Methods: We analyzed the records of 34 patients who had undergone surgical resection of lung cancer, which appeared as small solid nodules on initial CT findings. We studied the CT findings, volume doubling times (VDT), follow- up durations, pathological and clinical findings.Results: VDT is classified as follows: (1) slow growth group (SGG), with a VDT of more than 700 days and (2) rapid growth group (RGG), with a VDT of less than 700 days. The median VDT of the SGG was 1083 days, and the RGG was 256 days (p < 0.01). The median duration for follow- up of the SGG was 1218 days, and 179 days for the RGG. A statistical difference was noted in the follow- up durations (p < 0.01). There were no statistical differences in the preoperative thin- section CT (TSCT) findings, or in the pathological findings. The RGG included more patients with smoking histories. The CT findings of RGG tended to reveal changed in base lung field such as emphysema, and lung fibrosis.Conclusions: Generally, lung cancer appearing as small solid nodules on initial CT findings grew rapidly, but there were some cases which displayed slow growth patterns. These cases required follow up for over two years, before diagnosis was possible. We concluded the appropriate maximum followup duration is three years. (C) 2011 Elsevier Ireland Ltd. All rights reserved.