Problems associated with spin trapping oxygen-centered free radicals in biological systems.
Problems associated with spin trapping oxygen-centered free radicals in biological systems.
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DOI：
10.1016/0003-2697(89)90002-x
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发表时间：
1989-02
影响因子：
2.9
通讯作者：
S. Pou;D. Hassett;B. Britigan;M. Cohen;G. Rosen
中科院分区：
文献类型：
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作者：
S. Pou;D. Hassett;B. Britigan;M. Cohen;G. Rosen
由于超氧自由基和羟基自由基似乎是生物产生的最重要的以氧为中心的自由基，因此，由于亚硝基化合物与这些自由基反应产生的硝基氧快速分解，硝酮已成为主要的自旋陷阱 (8)。在用作自旋陷阱的几种硝酮中，5, 5-二甲基-l-吡咯啉-l-氧化物 (DMPO)’受到了最多的关注 (5-7, 9)。反应-
Since superoxide and hydroxyl radicals appear to be the most important oxygen-centered free radicals generated biologically, nitrones have emerged as the principal spin traps due to the rapid decomposition of the nitroxides derived from the reaction of nitroso compounds with these free radicals (8). Among several nitrones used as spin traps, 5, 5-dimethyl-l-pyrroline-l-oxide (DMPO)’has received the most attention (5-7, 9). Reac-