There are Different Kinds of Retinal Light Damage in the Rat
There are Different Kinds of Retinal Light Damage in the Rat
复制标题
大鼠视网膜光损伤有多种类型
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
W. Noell
中科院分区：
文献类型：
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作者：
W. Noell
下面我回顾一下我们实验室近15年来关于光破坏作用的实验结果。我的目的是区分至少两种不同的由光引起的视网膜病理。光是否通过一种或几种机制发挥其破坏作用的问题从我们研究一开始就困扰着我们，即一旦确定普通品种的白化或色素大鼠的视细胞和色素上皮会因长期暴露于中等甚至弱强度的可见光而受到不可逆转的影响和破坏。这个问题阻碍了分析效应机制和评估影响效应大小的物理和生物因素的实验计划，而必须找到可靠的定量测量方法。
In the following, I will review experimental results of our laboratory during the last 15 years on the damaging effect of light. My purpose will be to distinguish between at least two different kinds of retinal pathology caused by light. The question whether light exerts its damaging effect by one or several mechanisms has plagued us from the very beginning of our study, i.e. once it had been ascertained that the visual cells and the pigment epithelium of common breeds of albino or pigmented rats are irreversibly affected and destroyed by prolonged exposure to visible light of moderate or even weak intensity. The question inhibited the planning of experiments for the analysis of the mechanism of the effect and for the evaluation of physical and biological factors that influence the magnitude of the effect for which a reliable quantitative measure had to be found.