CAFFEINE AS AN ANALGESIC ADJUVANT
CAFFEINE AS AN ANALGESIC ADJUVANT
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DOI：
10.1001/jama.251.13.1711
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发表时间：
1984-01-01
影响因子：
120.7
通讯作者：
RUBIN, A
中科院分区：
文献类型：
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作者：
LASKA, EM;SUNSHINE, A;RUBIN, A
对过去20年间进行的涉及10,000多名患者的临床研究(30项)进行了分析，以评估咖啡因作为止痛辅助剂的价值。虽然大多数研究包括产后子宫痉挛或会切开疼痛的患者，但也有一些研究涉及口腔手术或头痛的患者。在26项研究中的21项中，含有咖啡因的止痛药与不含咖啡因的止痛药的相对效力估计大于1。几种主要类别的联合止痛药中每一种的汇集相对效力估计值都明显大于1。总体综合相对效力估计为1.41，95%可信限为1.23-1.63；也就是说，不含咖啡因的止痛药需要比含咖啡因的止痛剂大约40%的剂量才能获得相同数量的反应。
Clinical studies (30) involving more than 10,000 patients conducted during the last 20 yr were analyzed to assess the value of caffeine as an analgesic adjuvant. Although most studies included patients with postpartum uterine cramping or episiotomy pain, some involved patients with pain from oral surgery or headache. In 21 of 26 studies, the relative potency estimates of an analgesic with caffeine to an analgesic without caffeine is greater than one. The pooled relative potency estimates in each of several major categories of combination analgesics are significantly greater than one. The overall pooled relative potency estimate is 1.41, with 95% confidence limits of 1.23-1.63; that is, to obtain the same amount of response from an analgesic without caffeine requires a dose that is approximately 40% greater than one with caffeine.