Estrogenic activity of polychlorinated biphenyls present in human tissue and the environment
Estrogenic activity of polychlorinated biphenyls present in human tissue and the environment
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DOI：
10.1021/es051667u
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发表时间：
2006-04-15
影响因子：
11.4
通讯作者：
Soto, AM
中科院分区：
文献类型：
--
作者：
Decastro, BR;Korrick, SA;Soto, AM
本研究评价了环境介质和人体组织中存在的多氯联苯（PCB）的雌激素活性，并评估了新贝德福德MA（一个受PCB污染的超级基金场地）空气、土壤和灰尘中PCB衍生雌激素效力的暴露途径。使用E-SCREEN（一种基于MCF-7细胞体外雌激素依赖性增殖的测定方法）测定了34种PCB同系物的雌激素效力。儿童暴露于雌二醇当量通过多氯联苯在环境介质中估计加权以前报告的新贝德福德同系物的具体浓度，其相对雌激素的效力和公布的吸入和土壤摄入率。在E-SCREEN中，13种同系物具有弱雌激素性：多氯联苯17、18、30、44、49、66、74、82、99、103、110、128和179。这些多氯联苯的效力通常比17 β-雌二醇低6个数量级，增殖效力范围为0.0007%至0.0040%。在所评估的环境介质中，空气（吸入）的多氯联苯雌二醇当量接触量最高。从这项研究中获得的多氯联苯雌激素效力信息为初步估计人类接触异种雌激素的途径和应用于人类健康研究提供了重要资源，这些研究侧重于雌激素反应性健康结果，如生殖发育和相关恶性肿瘤。
This study evaluated the estrogenicity of polychlorinated biphenyls (PCBs) present in environmental media and human tissue and assessed exposure pathways for PCB-derived estrogenic potency in air, soil, and dust from New Bedford MA, an area with a PCB-contaminated Superfund site. Thirty-four PCB congeners were assayed for estrogenic potency using E-SCREEN, an assay based on the estrogen-dependent proliferation of MCF-7 cells in vitro. Childhood exposure to estradiol-equivalents via PCBs in environmental media was estimated by weighting previously reported New Bedford congener-specific concentrations by their relative estrogenic potency and published inhalation and soil ingestion rates. Thirteen congeners were weakly estrogenic in E-SCREEN: PCBs 17, 18, 30, 44, 49, 66, 74, 82, 99,103, 110, 128, and 179. These PCBs were typically 6 orders of magnitude less potent than 17 beta-estradiol, with proliferative potencies ranging from 0.0007% to 0.0040%. Of the environmental media assessed, air (inhalation) had the highest PCB-derived estradiol-equivalent exposure. PCB estrogenic potency information from this study provides an important resource both for preliminary estimation of routes of human exposure to xenoestrogens and for application to human health studies focused on estrogen-responsive health outcomes, such as reproductive development and related malignancies.