The Role of Tumor Associated Macrophages in Hepatocellular Carcinoma.
The Role of Tumor Associated Macrophages in Hepatocellular Carcinoma.
复制标题
肿瘤相关巨噬细胞在肝细胞癌中的作用
DOI：
10.7150/jca.51346
复制
发表时间：
2021
影响因子：
3.9
通讯作者：
Wang W
中科院分区：
文献类型：
--
作者：
Huang Y;Ge W;Zhou J;Gao B;Qian X;Wang W
肝细胞癌是世界范围内最常见的癌症之一，代表了炎症相关癌症的经典范例。各种与炎症相关的危险因素共同促进了肝脏慢性炎症的发展。慢性炎症反过来会导致肝脏持续的破坏-再生循环，促进肝细胞癌的发生和发展。肿瘤相关巨噬细胞在肝细胞癌的肿瘤微环境中大量存在，促进慢性炎症和肝细胞癌的进展。因此，更好地了解肿瘤相关巨噬细胞在肝细胞癌发病机制中的作用将有助于发展新的巨噬细胞靶向免疫疗法。本文综述了巨噬细胞促进肝细胞癌发生和发展的机制，以及正在进行的治疗和评估巨噬细胞调节疗法在肝细胞癌患者中的疗效的临床试验的信息。
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and represents a classic paradigm of inflammation-related cancer. Various inflammation-related risk factors jointly contribute to the development of chronic inflammation in the liver. Chronic inflammation, in turn, leads to continuous cycles of destruction-regeneration in the liver, contributing to HCC development and progression. Tumor associated macrophages are abundant in the tumor microenvironment of HCC, promoting chronic inflammation and HCC progression. Hence, better understanding of the mechanism by which tumor associated macrophages contribute to the pathogenesis of HCC would allow for the development of novel macrophage-targeting immunotherapies. This review summarizes the current knowledge regarding the mechanisms by which macrophages promote HCC development and progression, as well as information from ongoing therapies and clinical trials assessing the efficacy of macrophage-modulating therapies in HCC patients.
登录
查看更多内容
microRNA-26a 通过 PI3K/Akt 通路下调巨噬细胞集落刺激因子表达，从而抑制肝细胞癌中巨噬细胞的募集
影响因子：
28.5
作者：
Chai ZT;Zhu XD;Ao JY;Wang WQ;Gao DM;Kong J;Zhang N;Zhang YY;Ye BG;Ma DN;Cai H;Sun HC
通讯作者：
Sun HC
影响因子：
64.5
作者：
Bekkering, Siroon;Arts, Rob J. W.;Netea, Mihai G.
通讯作者：
Netea, Mihai G.
影响因子：
7.3
作者：
Elliott LA;Doherty GA;Sheahan K;Ryan EJ
通讯作者：
Ryan EJ
影响因子：
5.3
作者：
Coscia M;Quaglino E;Iezzi M;Curcio C;Pantaleoni F;Riganti C;Holen I;Mönkkönen H;Boccadoro M;Forni G;Musiani P;Bosia A;Cavallo F;Massaia M
通讯作者：
Massaia M
DOI：
10.1038/nri3071
发表时间：
2011-10-10
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--