Conservation and divergence in the transcriptional programs of the human and mouse immune systems
Conservation and divergence in the transcriptional programs of the human and mouse immune systems
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DOI：
10.1073/pnas.1222738110
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发表时间：
2013-02-19
影响因子：
11.1
通讯作者：
Regev, Aviv
中科院分区：
文献类型：
--
作者：
Shay, Tal;Jojic, Vladimir;Regev, Aviv
关于免疫系统中细胞分化和功能的大部分知识都来自小鼠的研究，但与人类免疫学，疾病和治疗的相关性受到了挑战，可能更多的是来自轶事而不是全面的证据。为此，我们比较了人类和小鼠免疫细胞类型转录谱的两个大型纲要。全局转录谱在相应的细胞谱系之间是保守的。大多数直向同源基因的表达模式是保守的，特别是对于谱系特异性基因。然而，数百个基因在所检查的细胞谱系中显示出明显不同的表达，其中169个基因即使在高度严格的标准下也表现出不同的表达。最后，监管机构的差异表达或丰富的顺式元件反映的监管机制是保守的物种之间，但在较低程度上，这表明不同的监管可能是一些保守的转录反应的基础。
Much of the knowledge about cell differentiation and function in the immune system has come from studies in mice, but the relevance to human immunology, diseases, and therapy has been challenged, perhaps more from anecdotal than comprehensive evidence. To this end, we compare two large compendia of transcriptional profiles of human and mouse immune cell types. Global transcription profiles are conserved between corresponding cell lineages. The expression patterns of most orthologous genes are conserved, particularly for lineage-specific genes. However, several hundred genes show clearly divergent expression across the examined cell lineages, and among them, 169 genes did so even with highly stringent criteria. Finally, regulatory mechanisms-reflected by regulators' differential expression or enriched cis-elements-are conserved between the species but to a lower degree, suggesting that distinct regulation may underlie some of the conserved transcriptional responses.