Effect sizes and test-retest reliability of the fMRI-based neurologic pain signature.
Effect sizes and test-retest reliability of the fMRI-based neurologic pain signature.
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DOI：
10.1016/j.neuroimage.2021.118844
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发表时间：
2022-02-15
期刊：
影响因子：
5.7
通讯作者：
Wager TD
中科院分区：
文献类型：
--
作者：
Han X;Ashar YK;Kragel P;Petre B;Schelkun V;Atlas LY;Chang LJ;Jepma M;Koban L;Losin EAR;Roy M;Woo CW;Wager TD
识别具有大效应量和高重测信度的预测心理状态的生物标志物是功能磁共振成像研究的一个日益重要的优先事项。我们研究了一个成熟的多变量脑测量，跟踪疼痛引起的伤害性输入，神经疼痛信号（NPSN）。在8项研究的N = 295名参与者中，在预测人内单次试验疼痛报告（d = 1.45）和预测疼痛报告的个体差异（d = 0.49）方面，平均响应显示出非常大的效应量。短期（一天内）重测信度（ICC = 0.84，平均69.5次试验/人）。可靠性与人内试验的数量成比例，需要≥60次试验才能获得良好的重测可靠性。在另外两项研究中，在5天（N = 29，ICC = 0.74，30次试验/人）和1个月（N = 40，ICC = 0.46，5次试验/人）的重测间隔内测试了可靠性。强烈的人内相关性和只有适度的人与人之间的相关性相结合的疼痛和疼痛的报告表明，这两个措施有不同的人与人之间的方差来源。疼痛指数不能替代疼痛报告中的个体差异，但可以作为疼痛相关生理学和干预机制目标的可靠测量。
Identifying biomarkers that predict mental states with large effect sizes and high test-retest reliability is a growing priority for fMRI research. We examined a well-established multivariate brain measure that tracks pain induced by nociceptive input, the Neurologic Pain Signature (NPS). In N = 295 participants across eight studies, NPS responses showed a very large effect size in predicting within-person single-trial pain reports (d = 1.45) and medium effect size in predicting individual differences in pain reports (d = 0.49). The NPS showed excellent short-term (within-day) test-retest reliability (ICC = 0.84, with average 69.5 trials/person). Reliability scaled with the number of trials within-person, with ≥60 trials required for excellent test-retest reliability. Reliability was tested in two additional studies across 5-day (N = 29, ICC = 0.74, 30 trials/person) and 1-month (N = 40, ICC = 0.46, 5 trials/person) test-retest intervals. The combination of strong within-person correlations and only modest between-person correlations between the NPS and pain reports indicate that the two measures have different sources of between-person variance. The NPS is not a surrogate for individual differences in pain reports but can serve as a reliable measure of pain-related physiology and mechanistic target for interventions.
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