Palm-sized biodetection system based on localized surface plasmon resonance
Palm-sized biodetection system based on localized surface plasmon resonance
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DOI：
10.1021/ac800335q
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发表时间：
2008-08-01
影响因子：
7.4
通讯作者：
Reboud, Julien
中科院分区：
文献类型：
--
作者：
Neuzil, Pavel;Reboud, Julien
我们提出了一个完整的手掌大小，电池供电的生物检测系统的基础上高度敏感的局部表面等离子体共振（LSPR）。我们用四个脉冲供电的发光二极管（LED）取代了光谱分析仪，每个LED都有不同的发射光谱。来自所有LED的反射光束由单个光电二极管检测。其复合输出电流由一个四通道锁相放大器解复用。使用覆盖有不同浓度的乙醇/水和2-丙醇/水的混合物的LSPR芯片来证明器件性能。该小型化系统不需要任何外部电源或个人计算机，因此适用于护理点和现场应用。
We present a complete palm-sized, battery-operated biodetection system based on highly sensitive localized surface plasmon resonance (LSPR). We have replaced the spectrum analyzer by four pulse-powered light-emitting diodes (LED), each with different emission spectra. The reflected light beams from all LEDs were detected by a single photodiode. Its composite output current was demultiplexed by a four-channel lock-in amplifier. Device performance was demonstrated using an LSPR chip covered with a mixture of ethanol/water and 2-propanol/water at different concentrations. The miniaturized system does not require any external power supply or personal computer and it is therefore suitable for point-of-care and field applications.