Long-term results of pars plana vitrectomy as an anti-inflammatory therapy of pediatric intermediate uveitis resistant to standard medical treatment
Long-term results of pars plana vitrectomy as an anti-inflammatory therapy of pediatric intermediate uveitis resistant to standard medical treatment
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DOI：
10.5301/ejo.5001020
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发表时间：
2018-01-01
影响因子：
1.7
通讯作者：
Dotrelova, Dagmar
中科院分区：
文献类型：
--
作者：
Darsova, Denisa;Pochop, Pavel;Dotrelova, Dagmar
目的：评价睫状体平坦部玻璃体切除术（PPV）作为儿童复发性中间葡萄膜炎的抗炎治疗的有效性。方法：一项回顾性研究评价了6名儿童（平均年龄8岁，范围6-12岁）接受PPV治疗中间葡萄膜炎的长期结果，平均观察期为10.3年（范围7-15.6年）。以标准方式对10只眼睛进行睫状体平坦部玻璃体切除术，并通过玻璃体取样进行实验室检查。记录的数据是围手术期或术后玻璃体切除术并发症，解剖和功能的PPV的结果，术前和术后最佳矫正Snellen visual acuity.Results：没有观察到围手术期或术后并发症。细菌学，病毒学，肌细胞学和玻璃体细胞学分析均为阴性。5只眼随后因后囊下白内障接受手术。术前平均视力0.32，术后平均视力0.8。结论：在儿童葡萄膜炎全身免疫抑制治疗失败的情况下，特别是在黄斑囊样水肿的眼睛，我们建议相对早期的PPV。
Purpose: To evaluate the efficacy of pars plana vitrectomy (PPV) as an anti-inflammatory therapy in pediatric recurrent intermediate uveitis.Methods: A retrospective study evaluated the long-term results of PPV indicated for intermediate uveitis with a mean observation period of 10.3 years (range 7-15.6 years) in 6 children (mean age 8 years, range 6-12 years). Pars plana vitrectomy was performed on 10 eyes in the standard manner and was initiated by vitreous sampling for laboratory examination. Data recorded were perioperative or postoperative vitrectomy complications, anatomic and functional results of PPV, and preoperative and postoperative best-corrected Snellen visual acuity.Results: No perioperative or postoperative complications were observed. Bacteriologic, virologic, mycotic, and cytologic analysis of the vitreous was negative in all tested children. Five eyes were subsequently operated on for posterior subcapsular cataracts. An average preoperative visual acuity of 0.32 improved to an average postoperative visual acuity of 0.8.Conclusions: In the case of systemic immunosuppressive treatment failure in pediatric uveitis, particularly in eyes with cystoid macular edema, we recommend PPV relatively early.