Surfactant alteration and replacement in acute respiratory distress syndrome.
Surfactant alteration and replacement in acute respiratory distress syndrome.
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DOI：
10.1186/rr86
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发表时间：
2001
影响因子：
5.8
通讯作者：
Seeger W
中科院分区：
文献类型：
--
作者：
Günther A;Ruppert C;Schmidt R;Markart P;Grimminger F;Walmrath D;Seeger W
急性呼吸窘迫综合征(ARDS)是一种常见的危及生命的疾病，在这种疾病中，反复观察到肺泡表面张力显著增加。其原因包括缺乏表面活性物质，磷脂、脂肪酸、中性脂和表面活性物质的组成发生变化，细胞外表面活性物质亚型分布失衡，血浆蛋白泄漏抑制表面活性物质的功能，表面活性物质磷脂和载脂蛋白进入纤维蛋白聚合体，以及炎症介质对表面活性物质的损伤/抑制。现在有很好的证据表明，这些表面活性物质的异常促进了肺泡的不稳定和塌陷，从而导致了顺应性的丧失和ARDS中所见的严重的气体交换异常。在最近进行的初步研究中，气体交换性能的急剧改善以及表面活性剂性能的深远恢复都遇到了困难。本文就ARDS中肺表面活性物质变化的种类和严重程度、这些变化在肺衰竭中的作用以及表面活性物质在ARDS治疗中的作用作一综述。
The acute respiratory distress syndrome (ARDS) is a frequent, life-threatening disease in which a marked increase in alveolar surface tension has been repeatedly observed. It is caused by factors including a lack of surface-active compounds, changes in the phospholipid, fatty acid, neutral lipid, and surfactant apoprotein composition, imbalance of the extracellular surfactant subtype distribution, inhibition of surfactant function by plasma protein leakage, incorporation of surfactant phospholipids and apoproteins into polymerizing fibrin, and damage/inhibition of surfactant compounds by inflammatory mediators. There is now good evidence that these surfactant abnormalities promote alveolar instability and collapse and, consequently, loss of compliance and the profound gas exchange abnormalities seen in ARDS. An acute improvement of gas exchange properties together with a far-reaching restoration of surfactant properties was encountered in recently performed pilot studies. Here we summarize what is known about the kind and severity of surfactant changes occuring in ARDS, the contribution of these changes to lung failure, and the role of surfactant administration for therapy of ARDS.
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DOI：
10.1164/ajrccm.160.6.9811084
发表时间：
1999-12-01
影响因子：
24.7
作者：
Armstrong, L;Thickett, DR;Millar, AB
通讯作者：
Millar, AB
DOI：
10.1164/ajrccm.160.6.9901117
发表时间：
1999-12-01
影响因子：
24.7
作者：
Greene, KE;Wright, JR;Martin, TR
通讯作者：
Martin, TR
影响因子：
3.3
作者：
FUCHIMUKAI, T;FUJIWARA, T;ENHORNING, G
通讯作者：
ENHORNING, G
影响因子：
168.9
作者：
Ainsworth, SB;Beresford, MW;Platt, MPW
通讯作者：
Platt, MPW
影响因子：
15.9
作者：
COONROD, JD;LESTER, RL;HSU, LC
通讯作者：
HSU, LC